Invasive Vulval Paget’s disease treated with primary radiotherapy: A rare case report and literature review

• Published in: Gynecologic oncology reports Vol. 34; p. 100674
• Main Authors: Sarkar, Avir, Saha, S.C., Sikka, Pooja, Kumari, Neha, Dey, Pranab, Rai, Bhavana
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-11-2020; Elsevier
• Subjects: Case Report; Neoplasm; Paget’s disease; Radiotherapy; Vulva; Neoplasm; Vulva; Radiotherapy; Paget’s disease
• ISSN: 2352-5789; 2352-5789
• DOI: 10.1016/j.gore.2020.100674

•A rare case of Vulval Paget’s Disease (VPD) treated with primary Radiotherapy(RT)•Till date only 14 cases of VPD have been treated with primary RT in literature.•This case is probably the 15th case to be reported.•Invasive VPD in perimenopausal age group is very rare as was in this case.•Role of radiotherapy for treating invasive VPD is still not established in literature.
Extramammary Vulval Paget’s Disease (VPD) is rare neoplasm of post-menopausal women. In relatively young perimenopausal patients, it can cause both diagnostic dilemma and therapeutic challenges. Majority of VPD is of non-invasive variety. Among invasive Paget’s disease, only 20% cases show invasion more than 1 mm. The present report describes a unique case of an invasive extra-mammary VPD with depth of invasion more than 4 mm presenting at a relatively young perimenopausal lady. Only 14 cases of VPD has been treated with primary radiotherapy in literature till date. We report this case to be the 15th case where radiotherapy was solely used to treat an invasive VPD.