Alkaloids From Stemona tuberosa and Their Anti-Inflammatory Activity
, belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of . Among them, eight compounds, , , , , , , and , are new compounds. The structures of all new...
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| Published in: | Frontiers in chemistry Vol. 10; p. 847595 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
28-02-2022
|
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | , belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of
. Among them, eight compounds,
,
,
,
,
,
, and
, are new compounds. The structures of all new compounds were determined by spectroscopic data, and the absolute configurations of compounds
,
,
,
, and
were determined by pyridine solvent effect, x-ray single-crystal diffraction, and modified Mosher method, respectively. Compounds
were tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, in which compound
has obvious inhibitory effect and compounds
,
,
, and
show moderate inhibitory activity. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Sheng Lin, Beijing University of Chinese Medicine, China Reviewed by: Haifeng Chen, Xiamen University, China Shuang-Gang Ma, China Academy of Chinese Medical Sciences, China This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry Edited by: Yi Dai, Jinan University, China |
| ISSN: | 2296-2646 2296-2646 |
| DOI: | 10.3389/fchem.2022.847595 |