Relationship Between Dietary Fiber and Vitamin C Intake and Oral Cancer

• Published in: Frontiers in public health Vol. 10; p. 880506
• Main Authors: Wang, Jing, Fan, Yi, Qian, Jiawen, Wang, Sijie, Li, Yanni, Xu, Mingming, Chen, Fa, Qiu, Yu, Lin, Lisong, He, Baochang, Liu, Fengqiong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12-05-2022
• Subjects: case-control; dietary fiber; food frequency questionnaires; oral cancer; Public Health; vitamin C; food frequency questionnaires; case-control; dietary fiber; vitamin C; oral cancer
• ISSN: 2296-2565; 2296-2565
• DOI: 10.3389/fpubh.2022.880506

Dietary fiber and vitamin C has been reported to play a possible role in tumorigenesis. However, few studies have estimated their association with oral cancer risk. In this project, we investigated the relationship between dietary fiber and vitamin C and oral cancer risk in adults in Southern China.
382 patients newly diagnosed with oral cancer were matched to 382 hospital derived controls by frequency matching in age and sex. Pre-diagnostic consumption of dietary fiber and vitamin C intake were measured through food frequency questionnaire. Association between nutrients intake and oral cancer risk were evaluated by logistic regression. OR value and 95% confidence interval was calculated.
Intake of dietary fiber and vitamin C was significantly lower in oral cancer patients (8.15 g/day) than in control participants (8.88 g/day). Increased dietary fiber or vitamin C intake was linked to a decreased incidence of OC after adjustment of age, marital status, residence, BMI, occupation, education, tobacco smoking, alcohol consumption and family history of cancer
< 0.001). Compared with the lowest tertile, the adjusted OR of the top tertile of dietary fiber was 0.47 (95 % CI 0.32, 0.68). While the adjusted OR of the highest tertile was 0.60 (95 % CI 0.42, 0.87) compared with the lowest tertile of vitamin C.
Dietary intake of fiber and vitamin C were lower in oral cancer patients than in control participants. Dietary fiber and vitamin C were inversely related to risk of oral cancer risk.