Comparison of laparoscopic versus open liver tumor resection: a case-controlled study

• Published in: Surgical endoscopy Vol. 23; no. 4; pp. 847 - 853
• Main Authors: Tsinberg, Michael, Tellioglu, Gurkan, Simpfendorfer, Conrad H., Walsh, Matthew R., Vogt, David, Fung, John, Berber, Eren
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01-04-2009; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Biological and medical sciences; Digestive system. Abdomen; Endoscopy; Female; Gastroenterology; General aspects; Gynecology; Hepatectomy - methods; Hepatology; Humans; Incidence; Investigative techniques, diagnostic techniques (general aspects); Laparoscopy - methods; Laparotomy - methods; Liver Neoplasms - surgery; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Postoperative Complications - epidemiology; Proctology; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Treatment Outcome; United States - epidemiology; United States; Laparoscopic liver resection; Cost analysis; Open liver resection; Human; Laparoscopic liver resections; Endoscopic surgery; Laparoscopy; Hepatectomy; Case study; Medicine; Treatment; Liver tumor; Endoscopy; Comparative study
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-008-0262-9

Background
Although there are data in the literature about the safety and efficacy of laparoscopic liver resections, there are not many studies comparing laparoscopic versus open approaches in a case-matched design. The purpose of this study is to compare the perioperative outcome of laparoscopic versus open liver resections from a single institution.
Methods
Thirty-one patients underwent laparoscopic liver resection between April 1997 and August 2007, with a prospective laparoscopic program started in April 2006 (
n
 = 25). This group of patients was compared with 43 consecutive patients undergoing open resection who were matched by size of the lesion (5 cm or less for malignant and 8 cm or less for benign), anatomical location (segments 2, 3, 4b, 5, 6), and type of resection (wedge resection, segmentectomy, partial liver resection). Data were obtained from medical records as well as from a prospective database. Statistical analysis was performed using
t
-test and chi-square. All data are expressed as mean ± standard error on the mean (SEM).
Results
Mean age in the laparoscopic group was 57.6 ± 2.7 years versus 61.9 ± 2.3 years in the open group (
p
 = 0.2). There were more women in the laparoscopic group [74% females (
n
 = 23) and 26% males (
n
 = 8)] versus in the open group [40% females (
n
 = 17) and 60% males (
n
 = 26)] (
p
 = 0.003). There were more patients with malignant lesions in the open group (73%) versus in the laparoscopic group (45%) (
p
 = 0.01). Eight patients underwent partial and 23 patients segmental/wedge liver resection in the laparoscopic group versus 15 patients who underwent partial and 28 patients segmental/wedge liver resection in the open group (
p
 = 0.7). Mean tumor size was 3.9 ± 0.4 cm in the laparoscopic group versus 4.2 ± 0.3 cm in the open group (
p
 = 0.5). Ten (32%) out of 31 cases in the laparoscopic group were hand-assisted. Inflow occlusion was used in 1 case (3%) in the laparoscopic group versus 16 (37.2%) in the open group. Mean operating time was 201 ± 15 min for the laparoscopic group and 172 ± 12 min for the open group (
p
 = 0.1). Mean estimated blood loss during the procedure was 122.5 ± 45.4 cc for the laparoscopic group and 299.6 ± 33.6 cc for the open group (
p
 = 0.002). Surgical margin was similar for malignant cases in both groups. Mean hospital stay was 3.2 ± 1.0 days for the laparoscopic group and 6.8 ± 0.7 days for the open group (
p
 = 0.004). The incidence of postoperative complications was 13% (
n
 = 4) in the laparoscopic and 16% (
n
 = 7) in the open group (
p
 = 0.7).
Conclusion
This study shows that, with a longer operative time, the laparoscopic approach, despite the learning curve, offers advantages regarding operative blood loss, postoperative analgesic requirement, time to regular diet, hospital stay, and overall cost compared with the open approach for minor liver resections.