Biotechnological Innovations and Therapeutic Application of Pediococcus and Lactic Acid Bacteria: The Next-Generation Microorganism

• Published in: Frontiers in bioengineering and biotechnology Vol. 9; p. 802031
• Main Authors: Peter, Sunday Bulus, Qiao, Zhina, Godspower, Hero Nmeri, Ajeje, Samaila Boyi, Xu, Meijuan, Zhang, Xian, Yang, Taowei, Rao, Zhiming
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14-02-2022
• Subjects: bacteriocin; Bioengineering and Biotechnology; biotherapeutics; deep neural network; genome editing; Pediococcus; probiotics; biotherapeutics; genome editing; Pediococcus; bacteriocin; deep neural network; probiotics
• ISSN: 2296-4185; 2296-4185
• DOI: 10.3389/fbioe.2021.802031

Lactic acid bacteria represent a worthwhile organism within the microbial consortium for the food sector, health, and biotechnological applications. They tend to offer high stability to environmental conditions, with an indicated increase in product yield, alongside their moderate antimicrobial activity. Lack of endotoxins and inclusion bodies, extracellular secretion, and surface display with other unique properties, are all winning attributes of these Gram-positive lactic acid bacteria, of which,
is progressively becoming an attractive and promising host, as the next-generation probiotic comparable with other well-known model systems. Here, we presented the biotechnological developments in
bacteriocin expression system, contemporary variegated models of
and lactic acid bacteria strains as microbial cell factory, most recent applications as possible live delivery vector for use as therapeutics, as well as upsurging challenges and future perspective. With the radical introduction of artificial intelligence and neural network in Synthetic Biology, the microbial usage of lactic acid bacteria as an alternative eco-friendly strain, with safe use properties compared with the already known conventional strains is expected to see an increase in various food and biotechnological applications in years to come as it offers better hope of safety, accuracy, and higher efficiency.