Luteinizing Hormone Releasing Hormone Increases Proliferation of Meningioma Cells In Vitro

• Published in: Archives of physiology and biochemistry Vol. 107; no. 4; pp. 286 - 291
• Main Authors: Durmaz, R., Deliorman, S., Isiksoy, S., Uyar, R., Tel, E.
• Format: Journal Article
• Language: English
• Published: Basingstoke Informa UK Ltd 01-01-1999; Taylor & Francis
• Subjects: Biological and medical sciences; Cell Division - drug effects; Female; Humans; Medical sciences; Meningeal Neoplasms - metabolism; Meningeal Neoplasms - pathology; Meningioma - metabolism; Meningioma - pathology; Neurology; Receptors, LHRH - metabolism; Tumor Cells, Cultured; Tumors of the nervous system. Phacomatoses; Hypothalamic hormone; Human; Cell proliferation; Nervous system diseases; Gonadotropin RH; Stimulation; Benign neoplasm; Hormone releasing factor; In vitro; Meningioma
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1076/13813455199908107041QFT286

The fact that meningioma shows at least a 2:1 predilection for women over men is considered to be due to endocrinological and paracrine regulation of the development of this tumour. The presence of receptors for the luteinizing hormone releasing hormone (LHRH) in gynaecological cancer permits the use of LHRH agonistic or antagonistic analogues with a direct effect or by the gonadpituitary axis suppression in the treatment of these tumours. Therefore, the effect of LHRH on meningioma cells is tested in this study. Meningioma cells from three female patients were cultured and LHRH (50 ng/ml) was added to the growth medium daily, for fourteen days. At the end of this period the cells were counted by means of a Coulter Counter. The stimulating effects of LHRH on the increase of the amount of cells in the meningioma monolayer culture were 146% (p < 0.01), 134% (p < 0.05) and 141% (p < 0.05) of the control, respectively, for the three patients.