Identification of Two Subsets of Murine DC1 Dendritic Cells That Differ by Surface Phenotype, Gene Expression, and Function
Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8 Irf8 Batf3 dependent (DC1) subset, and a CD8 Irf4 (DC2) subset. We found that the CD8 DC1 subset can be further divided into CD8 DC1a and CD8 DC1b subsets b...
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| Published in: | Frontiers in immunology Vol. 12; p. 746469 |
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| Abstract | Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8
Irf8
Batf3 dependent (DC1) subset, and a CD8
Irf4
(DC2) subset. We found that the CD8
DC1 subset can be further divided into CD8
DC1a and CD8
DC1b subsets by differences in surface receptors, gene expression, and function. Whereas all 3 DC subsets can act alone to induce potent Th1 cytokine responses to class I and II MHC restricted peptides derived from ovalbumin (OVA) by OT-I and OT-II transgenic T cells, only the DC1b subset could effectively present glycolipid antigens to natural killer T (NKT) cells. Vaccination with OVA protein pulsed DC1b and DC2 cells were more effective in reducing the growth of the B16-OVA melanoma as compared to pulsed DC1a cells in wild type mice. In conclusion, the Batf3-/- dependent DC1 cells can be further divided into two subsets with different immune functional profiles
and
. |
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| AbstractList | Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8
Irf8
Batf3 dependent (DC1) subset, and a CD8
Irf4
(DC2) subset. We found that the CD8
DC1 subset can be further divided into CD8
DC1a and CD8
DC1b subsets by differences in surface receptors, gene expression, and function. Whereas all 3 DC subsets can act alone to induce potent Th1 cytokine responses to class I and II MHC restricted peptides derived from ovalbumin (OVA) by OT-I and OT-II transgenic T cells, only the DC1b subset could effectively present glycolipid antigens to natural killer T (NKT) cells. Vaccination with OVA protein pulsed DC1b and DC2 cells were more effective in reducing the growth of the B16-OVA melanoma as compared to pulsed DC1a cells in wild type mice. In conclusion, the Batf3-/- dependent DC1 cells can be further divided into two subsets with different immune functional profiles
and
. Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8 + Irf8 + Batf3 dependent (DC1) subset, and a CD8 - Irf4 + (DC2) subset. We found that the CD8 + DC1 subset can be further divided into CD8 + DC1a and CD8 + DC1b subsets by differences in surface receptors, gene expression, and function. Whereas all 3 DC subsets can act alone to induce potent Th1 cytokine responses to class I and II MHC restricted peptides derived from ovalbumin (OVA) by OT-I and OT-II transgenic T cells, only the DC1b subset could effectively present glycolipid antigens to natural killer T (NKT) cells. Vaccination with OVA protein pulsed DC1b and DC2 cells were more effective in reducing the growth of the B16-OVA melanoma as compared to pulsed DC1a cells in wild type mice. In conclusion, the Batf3-/- dependent DC1 cells can be further divided into two subsets with different immune functional profiles in vitro and in vivo . Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8+Irf8+Batf3 dependent (DC1) subset, and a CD8-Irf4+ (DC2) subset. We found that the CD8+DC1 subset can be further divided into CD8+DC1a and CD8+DC1b subsets by differences in surface receptors, gene expression, and function. Whereas all 3 DC subsets can act alone to induce potent Th1 cytokine responses to class I and II MHC restricted peptides derived from ovalbumin (OVA) by OT-I and OT-II transgenic T cells, only the DC1b subset could effectively present glycolipid antigens to natural killer T (NKT) cells. Vaccination with OVA protein pulsed DC1b and DC2 cells were more effective in reducing the growth of the B16-OVA melanoma as compared to pulsed DC1a cells in wild type mice. In conclusion, the Batf3-/- dependent DC1 cells can be further divided into two subsets with different immune functional profiles in vitro and in vivo. |
| Author | Meyer, Everett Hongo, David Engleman, Edgar G Pawar, Rahul D Strober, Samuel Zheng, Pingping Dutt, Suparna |
| AuthorAffiliation | 1 Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine , Stanford, CA , United States 2 Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine , Stanford, CA , United States 3 Department of Pathology, Stanford University School of Medicine , Stanford, CA , United States |
| AuthorAffiliation_xml | – name: 1 Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine , Stanford, CA , United States – name: 3 Department of Pathology, Stanford University School of Medicine , Stanford, CA , United States – name: 2 Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine , Stanford, CA , United States |
| Author_xml | – sequence: 1 givenname: David surname: Hongo fullname: Hongo, David organization: Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, United States – sequence: 2 givenname: Pingping surname: Zheng fullname: Zheng, Pingping organization: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, United States – sequence: 3 givenname: Suparna surname: Dutt fullname: Dutt, Suparna organization: Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, United States – sequence: 4 givenname: Rahul D surname: Pawar fullname: Pawar, Rahul D organization: Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, United States – sequence: 5 givenname: Everett surname: Meyer fullname: Meyer, Everett organization: Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, United States – sequence: 6 givenname: Edgar G surname: Engleman fullname: Engleman, Edgar G organization: Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States – sequence: 7 givenname: Samuel surname: Strober fullname: Strober, Samuel organization: Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, United States |
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| Copyright | Copyright © 2021 Hongo, Zheng, Dutt, Pawar, Meyer, Engleman and Strober. Copyright © 2021 Hongo, Zheng, Dutt, Pawar, Meyer, Engleman and Strober 2021 Hongo, Zheng, Dutt, Pawar, Meyer, Engleman and Strober |
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| Keywords | CD8 T cell CD4 T cell type I dendritic cells dendritic cells tumor vaccination type II dendritic cell |
| Language | English |
| License | Copyright © 2021 Hongo, Zheng, Dutt, Pawar, Meyer, Engleman and Strober. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Antigen Presenting Cell Biology, a section of the journal Frontiers in Immunology Edited by: Daniel Saban, Duke University, United States Reviewed by: Luc Van Kaer, Vanderbilt University, United States; Joana Dias, Vaccine Research Center (NIAID), United States |
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| Snippet | Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8
Irf8
Batf3... Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8 + Irf8 + Batf3... Classical dendritic cells (cDCs) in mice have been divided into 2 major subsets based on the expression of nuclear transcription factors: a CD8+Irf8+Batf3... |
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| Title | Identification of Two Subsets of Murine DC1 Dendritic Cells That Differ by Surface Phenotype, Gene Expression, and Function |
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