Autophagy in MHC Class II Presentation: Sampling from Within

MHC class II molecules usually present exogenous antigens, but peptidome analyses have also identified many antigens from cytosolic or nuclear sources. In this issue of Immunity, Schmid et al. (2007) show that MHC class II molecules can present these through autophagosomes.

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 26; no. 1; pp. 1 - 3
Main Authors:	Menéndez-Benito, Victoria, Neefjes, Jacques
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2007 Elsevier Limited
Subjects:	Animals Antigen Presentation - immunology Autophagy Autophagy - immunology Biosynthesis Enzymes Histocompatibility Antigens Class II - immunology Humans Peptides Phagosomes - immunology Proteins Women
Online Access:	Get full text
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Description
Summary:	MHC class II molecules usually present exogenous antigens, but peptidome analyses have also identified many antigens from cytosolic or nuclear sources. In this issue of Immunity, Schmid et al. (2007) show that MHC class II molecules can present these through autophagosomes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Commentary-2 ObjectType-Feature-4 ObjectType-Review-1 ObjectType-Article-3
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2007.01.005