Recent Progress and New Perspectives in Studying T Cell Responses to Allografts

• Published in: American journal of transplantation Vol. 10; no. 5; pp. 1117 - 1125
• Main Authors: Valujskikh, A., Baldwin, W. M., Fairchild, R. L.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01-05-2010; Wiley
• Subjects: Acute cellular rejection; Animals; Biological and medical sciences; Medical sciences; memory T cells; Mice; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; T-Lymphocytes - immunology; tolerance; Transplantation Tolerance - immunology; T‐cell immunity and transplantation; Graft(material); Immune response; Acute; Homograft; Tolerance; Cellular immunity; memory T cells; Memory lymphocyte; Rejection; Perspective; T-Lymphocyte; T cell immunity and transplantation; Graft; Cell; Acute cellular rejection
• ISSN: 1600-6135; 1600-6143
• DOI: 10.1111/j.1600-6143.2010.03087.x

Studies in the past decade advanced our understanding of the development, execution and regulation of T‐cell‐mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft‐prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.
Recent insights into development, execution and regulation of T cell mediated allograft rejection will shape the field of transplant immunology in the near future.