Towards Proto-Cells: "Primitive" Lipid Vesicles Encapsulating Giant DNA and Its Histone Complex

An important prebiotic event was probably the incorporation of nucleic acids by lipid vesicles. This process was studied with artificial model cells and fluorescent probes. Pictures 1–4 represent a time series of fluorescence microscopic images of T4 DNA molecules (166 kb) incorporated into giant ve...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 2; no. 6; pp. 457 - 459
Main Authors:	Nomura, Shin-ichirou M., Yoshikawa, Yuko, Yoshikawa, Kenichi, Dannenmuller, Olivier, Chasserot-Golaz, Sylvette, Ourisson, Guy, Nakatani, Yoichi
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag GmbH 01-06-2001 WILEY‐VCH Verlag GmbH
Subjects:	Bacteriophage T4 - genetics Diterpenes DNA - chemistry DNA - metabolism DNA - ultrastructure DNA structures Fluorescent Dyes - metabolism Lipids - chemistry membranes Microscopy, Confocal Molecular Structure Polyisoprenyl Phosphates - chemistry prebiotic chemistry single molecules Transport Vesicles - chemistry Transport Vesicles - metabolism vesicles
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Summary:	An important prebiotic event was probably the incorporation of nucleic acids by lipid vesicles. This process was studied with artificial model cells and fluorescent probes. Pictures 1–4 represent a time series of fluorescence microscopic images of T4 DNA molecules (166 kb) incorporated into giant vesicles of 5 μm diameter. The entrapped DNA molecules are in a coiled state.
Bibliography:	ark:/67375/WNG-JKLL8S3M-3 ArticleID:CBIC457 istex:FC99EC4DB339BA6CC1604F4885C260F21FE898B8 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1439-4227 1439-7633
DOI:	10.1002/1439-7633(20010601)2:6<457::AID-CBIC457>3.0.CO;2-F