MIDDLE EAR EFFUSION CONCENTRATIONS OF CEFIXIME DURING ACUTE OTITIS MEDIA WITH EFFUSION AND OTITIS MEDIA WITH EFFUSION

• Published in: The Pediatric infectious disease journal Vol. 16; no. 8; pp. 816 - 817
• Main Authors: Harrison, Christopher J, Chartrand, Stephen A, Rodriguez, William, Schwartz, Richard, Pollack, Jay, Thedinger, Britt, Block, Stan L, Hedrick, James A
• Format: Journal Article
• Language: English
• Published: Baltimore, MD Williams & Wilkins 01-08-1997; Philadelphia, PA Lippincott; Hagerstown, MD
• Subjects: Acute Disease; Bacterial diseases; Biological and medical sciences; Cefixime; Cefotaxime - analogs & derivatives; Cefotaxime - pharmacokinetics; Cephalosporins - pharmacokinetics; Child, Preschool; Ear, Middle - metabolism; Ent and stomatologic bacterial diseases; Human bacterial diseases; Humans; Infant; Infectious diseases; Medical sciences; Otitis Media with Effusion - drug therapy; Otitis Media with Effusion - metabolism; Human; Effusion; Middle ear disease; Acute; Clinical form; Concentration; Antibiotic; Chemotherapy; Treatment; Pathological fluid; ENT disease; Otitis media; Cefixime; Middle ear; Pharmacokinetics; Child
• ISSN: 0891-3668; 1532-0987
• DOI: 10.1097/00006454-199708000-00016

Cefixime is an oral cephalosporin with in vitro activity against Gram-positive and Gram-negative bacteria, including those pathogens commonly associated with acute otitis media with effusion (AOME), and otitis media with effusion (OME) in children. The MIC sub(90) values for cefixime vs. penicillin (PCN)-susceptible Streptococcus pneumoniae, Haemophilus influenzae (whether beta-lactamase-producing or not), and beta-lactamase-producing Morxella catarrhalis are 0.25, 0.06 and 0.50 mg/l, respectively. Concentrations needed to inhibit PCN-resistant pneumococci are >8 mg/l. Mean peak serum concentrations of cefixime occur 4 to 5 h post dosing and following a single oral dose of 8 mg /kg (the recommended dose for treating AOME) are reported to be 3.4 to 3.9 mg/l with an elimination phase half-life (t sub( one half ) beta) of 3 to 4 h. Cefixime is considered to be an effective agent for treatment of AOM in pediatric patients, particularly when betalactamase-producing H. influenzae and M. catarrhalis are present. However, there are no published data on middle ear fluid (MEE) concentrations of cefixime in children with either AOME or OME. The objective of this study was to compare serum concentrations to MEE concentrations of cefixime during AOME or OME.