Evaluation of in vivo Biological Activity Profile of Isoorientin

• Published in: Zeitschrift für Naturforschung C. A journal of biosciences Vol. 59; no. 11; pp. 787 - 790
• Main Authors: Küpeli, Esra, Aslan, Mustafa, Gürbüz, İlhan, Yesilada, Erdem
• Format: Journal Article
• Language: English
• Published: Germany Verlag der Zeitschrift für Naturforschung 01-12-2004
• Subjects: Analgesics - pharmacology; Animals; Anti-inflammatory Activity; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-nociceptive Activity; Carrageenan; Edema - chemically induced; Edema - drug therapy; Gastroprotective Effect; Gentiana - chemistry; Inflammation - chemically induced; Inflammation - drug therapy; Isoorientin; Luteolin - chemistry; Luteolin - isolation & purification; Luteolin - pharmacology; Male; Mice; Molecular Structure
• ISSN: 0939-5075; 1865-7125
• DOI: 10.1515/znc-2004-11-1204

Anti-nociceptive, anti-inflammatory and gastroprotective activities of the known C-glycosyl flavonoid, isoorientin, were studied in rats and mice. For the anti-nociceptive activity assessment the p-benzoquinone-induced writing test, for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice, and for the gastroprotective activity the EtOH-induced ulcerogenesis model in rats were used. Isoorientin was shown to possess significant anti-nociceptive and anti-inflammatory activities at 15 mg/kg and 30 mg/kg doses, without inducing any apparent acute toxicity as well as gastric damage. However, the compound did not possess any significant gastroprotective activity against EtOH-induced ulcerogenesis.