Clinical Implications of Initial Renal Function After Deceased Donor Transplant

• Published in: Transplantation proceedings Vol. 42; no. 4; pp. 1084 - 1089
• Main Authors: Guimarães-Souza, N, Dalboni, M.A, Canziani, M.E, Tedesco-Silva, H, Batista, M.C, Sesso, R, Câmara, N.O, Medina-Pestana, J.O, Pacheco-Silva, A, Cendoroglo, M
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01-05-2010; Elsevier
• Subjects: Anemia - epidemiology; Biological and medical sciences; Cadaver; Delayed Graft Function - epidemiology; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glomerular Filtration Rate; Graft Survival; Humans; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Kidney Function Tests; Kidney Transplantation - adverse effects; Kidney Transplantation - immunology; Kidney Transplantation - physiology; Medical sciences; Postoperative Complications - epidemiology; Renal Dialysis; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue Donors; Tissue, organ and graft immunology; Treatment Failure; Suboptimal donor; Human; Kidney disease; Urinary system disease; Renal function; Transplantation; Homotransplantation; Kidney; Medicine; Symptomatology; Treatment; Urinary system; Surgery; Graft; Cadaver
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2010.03.067

Abstract The aim of this study was to investigate whether slow graft function (SGF) after transplantation of deceased-donor kidneys affected the prevalence of anemia or the glomerular filtration rate (GFR). We retrospectively evaluated the records of 534 kidney transplant patients who were classified based on their initial renal function, namely, immediate graft function (IGF), slow graft function (SGF), or delayed graft function (DGF). Among the 534 kidney transplant patients studied, the occurrences of each condition were IGF 104, SGF 133, and DGF 297. Six months after transplantation, a greater percentage of DGF patients were anemic compared with the others ( P = .028). However, at 12 months after transplantation, SGF patients showed more anemia than the IGF group. DGF and SGF patients displayed similar GFR values at 18 and 24 months after transplantation. However, IGF patients displayed higher GFRs, even when subjects who experienced acute rejection episodes were censored ( P = .004). The incidence of acute rejection episodes was similar among SGF and DGF patients. Patients displaying SGF after deceased-donor transplantation showed a greater tendency to be anemic than those displaying IGF. This study also suggested that SGF patients were at risk for acute rejection episodes and/or significantly reduced kidney function as measured by GFR.