Triboelectric charging of polytetrafluoroethylene antithrombotic catheters

• Published in: Journal of artificial organs Vol. 22; no. 4; pp. 300 - 306
• Main Authors: Ogino, Minoru, Naemura, Kiyoshi, Sasaki, Satoshi, Minami, Junko, Kano, Takashi, Ito, Nana, Kasai, Ryosuke, Kamijyo, Fuminori, Kusumoto, Naoki, Akimoto, Kazuya, Tanaka, Kohei, Shinohara, Kazuhiko, Yokoyama, Kenji
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01-12-2019; Springer Nature B.V
• Subjects: Anticoagulants; Biomedical Engineering and Bioengineering; Blood coagulation; Blood vessels; Cardiac Surgery; Catheter-Related Infections - prevention & control; Catheters; Catheters, Indwelling; Charge distribution; Coagulase; Coagulation; Denaturation; Equipment Design; Fibrinolytic Agents - pharmacology; Heparin; Heparin - pharmacology; Humans; Irregularities; Medical instruments; Medicine; Medicine & Public Health; Nephrology; Original Article; Polytetrafluoroethylene; Rubbing; Solidification; Surface charge; Surface Properties; Thrombosis; Thrombosis - prevention & control; Tribo charging; Triboelectric effect; Tubes; U-Plasminogen activator; Urokinase; Anticoagulant; Electret; Intravascular indwelling catheter; Triboelectric charging
• ISSN: 1434-7229; 1619-0904
• DOI: 10.1007/s10047-019-01122-6

This study proposes that a polytetrafluoroethylene (PTFE) electret tube charged by frictional electricity can prevent the solidification of the indwelling catheter in blood vessels. Coagulation in intravascular indwelling catheters may discontinue the treatment because of thrombus-derived bacteria–adhesion infections or poor blood removal. Current commercially available intravascular catheters lack complete antithrombotic measures, even with heparin or urokinase antithrombotic coatings. Herein, we tested the effectiveness of an antithrombotic treatment that prevents coagulation using a static electric charge on the interior of the PTFE tube via the triboelectric effect by rubbing the tube’s inner wall with a round glass rod. The anticoagulation properties were evaluated by enclosing a sample of blood in an electret tube and observing the coagulase adhering to the inner wall using a microscope. To confirm the effectiveness of this treatment, the charge–distribution on the inner surface of the electret tube was measured, surface irregularities were observed, and the elements on the surface were analyzed. The surface potential inside the electret tube was − 366.4 V, which proved effective for an antithrombotic treatment, as it discouraged coagulation, and the triboelectric charging process caused neither surface element denaturation nor significant surface irregularities. The nearly uniform negative surface charge on the inside of the tube was responsible for the antithrombotic effect because no surface irregularities or change in the surface element denaturation was observed. Triboelectrically charged PTFE electret tubes are highly useful for intravascular indwelling catheters.