Persistence of high levels of blood soluble human leukocyte antigen-G is associated with rapid progression of HIV infection

• Published in: AIDS (London) Vol. 23; no. 11; pp. 1437 - 1440
• Main Authors: LAJOIE, Julie, FONTAINE, Julie, TREMBLAY, Cécile, ROUTY, Jean-Pierre, POUDRIER, Johanne, ROGER, Michel
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 17-07-2009
• Subjects: AIDS/HIV; Anti-HIV Agents - therapeutic use; Biological and medical sciences; Epidemiologic Methods; Histocompatibility Antigens Class I - blood; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1; HLA Antigens - blood; HLA-G Antigens; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Medical sciences; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Infection; Antigen; Human; Immunopathology; Prognosis; Leukocyte; Viral disease; Evolution; AIDS; Immune deficiency; Blood
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/QAD.0b013e32832d0825

Human leukocyte antigen-G is an important suppressor of the immune response, and HIV can modulate its expression. Longitudinal monitoring of soluble human leukocyte antigen-G plasma levels in patients with primary HIV infection undergoing different rates of disease progression showed that levels were elevated in the early phases of infection and remained high throughout follow-up in rapid progressors who responded to antiretroviral therapy but were restored to normal levels in the chronic phase of infection in both untreated normal progressors and long-term nonprogressors.