Evidence that multidrug resistance in Chinese hamster ovary cells is associated with alterations in the endoplasmic reticulum

Multidrug resistance (MDR) in animal and human cell lines is often associated with a reduction in cellular accumulation of the drugs concerned. The present study indicates that in addition to hyperexpression of V19/CP22/Sorcin and a high molecular weight glycoprotein family (P-glycoprotein) structur...

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Bibliographic Details
Published in:	British journal of cancer Vol. 56; no. 2; pp. 143 - 145
Main Authors:	REEVE, J. G, KOCH, G. L. E, TWENTYMAN, P. R
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-08-1987
Subjects:	Animals Antineoplastic agents Biological and medical sciences Biological Transport Calcium - pharmacokinetics Cell Line Cricetinae Cricetulus Drug Resistance endoplasmic reticulum Endoplasmic Reticulum - metabolism Female General aspects Medical sciences Membrane Glycoproteins - analysis Ovary Pharmacology. Drug treatments Antineoplastic agent Modification Multiple resistance Gene expression In vitro Endoplasmic reticulum Tumor cell CHO cell line Mechanism
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Summary:	Multidrug resistance (MDR) in animal and human cell lines is often associated with a reduction in cellular accumulation of the drugs concerned. The present study indicates that in addition to hyperexpression of V19/CP22/Sorcin and a high molecular weight glycoprotein family (P-glycoprotein) structural changes in the endoplasmic reticulum (ER) also occur in MDR CH super(R)C super(5) cells.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.1987.173