Porous, Hollow, and Ball-in-Ball Metal Oxide Microspheres: Preparation, Endocytosis, and Cytotoxicity
An inexpensive ultrasonic generator (household humidifier; ultrasonic spray pyrolysis) is used to synthesize porous, hollow, and ball‐in‐ball metal oxide microspheres (see figure). The morphology and pore size were controlled by the silica to TiIV ratio and silica particle size. With the introductio...
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| Published in: | Advanced materials (Weinheim) Vol. 18; no. 14; pp. 1832 - 1837 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Weinheim
WILEY-VCH Verlag
18-07-2006
WILEY‐VCH Verlag |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | An inexpensive ultrasonic generator (household humidifier; ultrasonic spray pyrolysis) is used to synthesize porous, hollow, and ball‐in‐ball metal oxide microspheres (see figure). The morphology and pore size were controlled by the silica to TiIV ratio and silica particle size. With the introduction of transition‐metal ions, core/shell‐type microspheres can be synthesized in a single‐pot synthesis. These nanomaterials are rapidly taken up into the cytoplasm (but not into the nucleus) of macrophages and show very little cell toxicity. |
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| Bibliography: | UIUC Center for Microanalysis of Materials, supported by the DOE - No. DEFG02-91-ER45439 NSF - No. CHE-03-15494 ArticleID:ADMA200600222 Harry G. Drickamer Fund BK 21 Human Life Sciences ark:/67375/WNG-MG1ZV1LT-X CRI We thank Prof. J. Lewis's group (UIUC) for use of their Zetasizer. Regarding cell work and manuscript discussions we thank Mr. K. Y. Shin, Dr. S. McMasters, and Ms. C. S. Lee. This work has been supported in part by the NSF (CHE-03-15494 to K. S. S.) and by the National Creative Research Initiative Grant from Ministry of Science and Technology and in part by BK 21 Human Life Sciences (to Y. H. S.). W. H. S. thanks Harry G. Drickamer Fund and A. R. J. thanks CRI for research fellowships. We thank the UIUC Center for Microanalysis of Materials, supported by the DOE under Grant DEFG02-91-ER45439. Supporting Information is available online from Wiley InterScience or from the author. National Creative Research Initiative Grant from Ministry of Science and Technology istex:E366BF0668BD1EBD01DDAB188F2F7C10A2BFE9F3 We thank Prof. J. Lewis's group (UIUC) for use of their Zetasizer. Regarding cell work and manuscript discussions we thank Mr. K. Y. Shin, Dr. S. McMasters, and Ms. C. S. Lee. This work has been supported in part by the NSF (CHE‐03‐15494 to K. S. S.) and by the National Creative Research Initiative Grant from Ministry of Science and Technology and in part by BK 21 Human Life Sciences (to Y. H. S.). W. H. S. thanks Harry G. Drickamer Fund and A. R. J. thanks CRI for research fellowships. We thank the UIUC Center for Microanalysis of Materials, supported by the DOE under Grant DEFG02‐91‐ER45439. Supporting Information is available online from Wiley InterScience or from the author. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| ISSN: | 0935-9648 1521-4095 |
| DOI: | 10.1002/adma.200600222 |