Nephroprotective and antioxidant effect of green tea ( Camellia sinensis ) against nicotine-induced nephrotoxicity in rats and characterization of its bioactive compounds by HPLC-DAD

• Published in: Applied physiology, nutrition, and metabolism Vol. 44; no. 11; p. 1134
• Main Authors: Ben Saad, Anouar, Ncib, Sana, Rjeibi, Ilhem, Saidi, Issam, Zouari, Nacim
• Format: Journal Article
• Language: English
• Published: Canada 01-11-2019
• Subjects: Animals; Antioxidants - pharmacology; Ascorbic Acid - analysis; Camellia sinensis - chemistry; Catalase - metabolism; Glutathione Peroxidase - metabolism; Kidney - drug effects; Male; Malondialdehyde - analysis; Nicotine - toxicity; Oxidative Stress; Protective Agents - pharmacology; Rats, Wistar; Superoxide Dismutase - metabolism; Tea - chemistry; Vitamin E - analysis; antioxidant; nicotine; kidney function; antioxydant; dommages oxydatifs; green tea; oxidative damage; fonction rénale; thé vert
• ISSN: 1715-5320
• DOI: 10.1139/apnm-2017-0834

Nicotine is a potential inducer of oxidative stress, through which it can damage numerous biological molecules. Natural antioxidants that prevent or slow the progression and severity of nicotine toxicity may have a significant health impact. The purpose of this study, conducted on Wistar rats, was to evaluate the beneficial effects of green tea (
) extract on nicotine treatment-induced damage on kidney. Our results showed that nicotine significantly (
< 0.01) increased serum and kidney malondialdehyde, the serum contents of urea, creatinine, and uric acid. In addition, nicotine intoxication significantly (
< 0.01) decreased the levels of vitamins E and C in serum and kidney tissue as well as the activities of superoxide dismutase, catalase, and glutathione peroxidase. Interestingly, animals that were pretreated with green tea, prior to nicotine administration, showed a significant nephroprotection, revealed by a significant reduction-induced oxidative damage for all tested markers. The nephroprotective activity of green tea is mediated, at least in part, by the antioxidant effect of its constituents.