Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait

• Published in: EJHaem Vol. 4; no. 3; pp. 705 - 709
• Main Authors: Gomes, Ingrid Cristiane Pereira, Magalhães, Lucas Sousa, Bomfim, Lays Gisele Santos, dos Santos, Priscila Lima, Silva, Roberto Jerônimo dos Santos, Cruz, Maria Carollyne Passos, Albuquerque, Lindemberg Costa, Neves, Victoria Haydée Deusdedith, Oliveira, Paula Gabriella Pereira Rosa, Carvalho, Alessandro Freire, Silva, Lucas Oliveira, Aragão, Matheus Todt, Moura, Tatiana Rodrigues, Cipolotti, Rosana
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-08-2023; John Wiley and Sons Inc; Wiley
• Subjects: adults; Anemia; Asymptomatic; Biomarkers; Cytokines; Dehydrogenases; Disease; Exercise; Hemoglobin; Inflammation; Interleukin 10; Interleukin 6; Interleukin 8; Myeloid cells; Neutrophils; Pathophysiology; Physical fitness; Short Report; Short Reports; Sickle cell anemia; Sickle cell disease; sickle cell trait; Tumor necrosis factor-TNF; cytokines; inflammation; sickle cell trait; adults; sickle cell anemia
• ISSN: 2688-6146; 2688-6146
• DOI: 10.1002/jha2.712

Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross‐sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL‐1β, IL‐6, IL‐10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL‐8/IL‐10 and soluble triggering receptor expressed on myeloid cells‐1/IL‐10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.