Correlations between CYP3A4 polymorphism and susceptibility to breast cancer in Chinese Han population

• Published in: International journal of clinical oncology Vol. 24; no. 2; pp. 179 - 188
• Main Authors: Liu, Xu, Huang, Xi, Zhang, Shanshan, Niu, Fanglin, Ouyang, Yongri, Shou, Zhexing, Liu, Jikui
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-02-2019; Springer Nature B.V
• Subjects: Asian Continental Ancestry Group - genetics; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - genetics; Cancer Research; Carcinogenesis; Case-Control Studies; China - epidemiology; CYP3A4 gene; Cytochrome P-450 CYP3A - genetics; Etiology; Female; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Health risk assessment; Humans; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Article; Polymorphism; Polymorphism, Single Nucleotide; Prognosis; Single-nucleotide polymorphism; Statistical analysis; Steroid hormones; Surgical Oncology; China; Breast cancer; gene; Susceptibility; Polymorphism; CYP3A4 gene
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-018-1346-8

Background
CYP3A4 is a major enzyme catalyzing the metabolism of endogenous steroids that play an important role in the etiology of carcinogenesis. This study was designed to investigate the contribution of
CYP3A4
polymorphism to breast cancer in Chinese Han female population.
Methods
To examine whether variants of
CYP3A4
contribute to breast cancer, 5 single-nucleotide polymorphisms (SNPs) of
CYP3A4
were genotyped by Sequenom MassARRAY in 267 breast cancer patients and 302 healthy controls. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age.
Results
We found that the TT genotype of
CYP3A4*1G
(rs2242480) polymorphism was associated with increased risk of breast cancer using the fixed effects model (recessive model: OR = 2.34,
p
 = 0.018). Stratified according to age, CYP3A4*1G increased the risk of breast cancer especially in less than 50-year-old group (codominant model OR = 3.68,
p
 = 0.041; recessive model: OR = 3.55,
p 
= 0.012). Furthermore, TT genotype of rs2242480 was associated with Cerb-B2 positive (recessive model: OR = 2.47,
p 
= 0.025) and stage I/II (recessive model: OR = 2.32,
p 
= 0.041). However, no statistically significant associations in other polymorphisms and haploview analysis were observed.
Conclusions
This study provides an evidence for polymorphism of
CYP3A4
gene associated with the development of breast cancer, also a new insight into etiology of breast cancer. However, the underlying mechanism of the
CYP3A4
gene in breast cancer is necessary for further study.