Safe pulmonary resection after chemotherapy and high-dose thoracic radiation

• Published in: The Annals of thoracic surgery Vol. 68; no. 2; pp. 316 - 320
• Main Authors: Sonett, Joshua R, Krasna, Mark J, Suntharalingam, Mohan, Schuetz, Julie, Doyle, L.Austin, Lilenbaum, Rogerio, Gamliel, Ziv
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01-08-1999
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Adult; Aged; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - therapy; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Length of Stay; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - therapy; Male; Middle Aged; Neoplasm Staging; Pneumonectomy; Postoperative Complications - etiology; Postoperative Complications - mortality; Radiotherapy Dosage; Radiotherapy, Adjuvant; Survival Rate
• ISSN: 0003-4975; 1552-6259
• DOI: 10.1016/S0003-4975(99)00593-7

Background. Pulmonary resection after high-dose thoracic irradiation is reported to be associated with a high morbidity and mortality, and has been considered to be prohibitive.
Methods. We report safe pulmonary resection in 19 consecutive patients receiving neoadjuvant therapy that included greater than 59 Gy thoracic radiation. The mean thoracic radiation dose was 61.8 Gy (range 59.5–66.5) and mean age was 52 years (range 36–72 years). Cell type was adenocarcinoma (6), squamous (7), and other non-small cell lung cancer (NSCLC) (6). Sixteen of 19 patients received concurrent chemotherapy. Median time from end of treatment to surgical resection was 89 days (range 22–258 days). Surgical resection included 13 lobectomies and six pneumonectomies (four right, two left).
Results. A complete pathologic response was seen in 8 of 19 (42%) patients. Three patients required intraoperative transfusion of blood. Mean intensive care unit stay was 2.0 days (range 1–8 days), and mean length of stay (LOS) was 8.0 days (range 3–18 days). There were four postoperative complications; one bronchopulmonary fistula, one subarachnoid-pleural fistula, and 2 patients with prolonged atelectasis. There was no incidence of acute respiratory distress syndrome (ARDS) or operative mortality.
Conclusions. Pulmonary resection, including pneumonectomy, after chemotherapy and high-dose thoracic radiation may be performed safely with a low rate of intraoperative and postoperative complications.