Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their pr...

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Bibliographic Details
Published in:	Translational lung cancer research Vol. 6; no. 1; pp. 68 - 75
Main Authors:	Gao, Jian-Wei, Rizzo, Stefania, Ma, Li-Hong, Qiu, Xiang-Yu, Warth, Arne, Seki, Nobuhiko, Hasegawa, Mizue, Zou, Jia-Wei, Li, Qian, Femia, Marco, Lv, Tang-Feng, Song, Yong
Format:	Journal Article
Language:	English
Published:	AME Publishing Company 01-02-2017
Subjects:	Review
Online Access:	Get full text
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Summary:	The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management. Our review focuses on the pathologic characteristics of GGO detected at CT, involving histopathology and molecular pathology.
Bibliography:	Contributions: (I) Conception and design: All authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
ISSN:	2218-6751 2226-4477
DOI:	10.21037/tlcr.2017.01.02