An Update on the Role of Adipose Tissues in Psoriasis

Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cro...

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Published in:	Frontiers in immunology Vol. 10; p. 1507
Main Authors:	Wong, Yisheng, Nakamizo, Satoshi, Tan, Kahbing J, Kabashima, Kenji
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 28-06-2019
Subjects:	adipocyte adipokine cytokines adipose tissue—obesity Immunology macrophage—cell obesity psoriasis macrophage—cell adipokine cytokines psoriasis adipocyte adipose tissue—obesity leptin obesity
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Abstract	Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
AbstractList	Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
Author	Wong, Yisheng Kabashima, Kenji Nakamizo, Satoshi Tan, Kahbing J
AuthorAffiliation	2 Singapore Immunology Network, Skin Research Institute of Singapore, A STAR , Singapore , Singapore 3 Department Dermatology, Kyoto University School of Medicine , Kyoto , Japan 1 National Skin Centre , Singapore , Singapore
AuthorAffiliation_xml	– name: 2 Singapore Immunology Network, Skin Research Institute of Singapore, A STAR , Singapore , Singapore – name: 3 Department Dermatology, Kyoto University School of Medicine , Kyoto , Japan – name: 1 National Skin Centre , Singapore , Singapore
Author_xml	– sequence: 1 givenname: Yisheng surname: Wong fullname: Wong, Yisheng organization: National Skin Centre, Singapore, Singapore – sequence: 2 givenname: Satoshi surname: Nakamizo fullname: Nakamizo, Satoshi organization: Singapore Immunology Network, Skin Research Institute of Singapore, ASTAR, Singapore, Singapore – sequence: 3 givenname: Kahbing J surname: Tan fullname: Tan, Kahbing J organization: Singapore Immunology Network, Skin Research Institute of Singapore, ASTAR, Singapore, Singapore – sequence: 4 givenname: Kenji surname: Kabashima fullname: Kabashima, Kenji organization: Department Dermatology, Kyoto University School of Medicine, Kyoto, Japan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31316526$$D View this record in MEDLINE/PubMed
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Copyright	Copyright © 2019 Wong, Nakamizo, Tan and Kabashima. 2019 Wong, Nakamizo, Tan and Kabashima
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Keywords	macrophage—cell adipokine cytokines psoriasis adipocyte adipose tissue—obesity leptin obesity
Language	English
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Snippet	Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has...
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SubjectTerms	adipocyte adipokine cytokines adipose tissue—obesity Immunology macrophage—cell obesity psoriasis
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Title	An Update on the Role of Adipose Tissues in Psoriasis
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