An Update on the Role of Adipose Tissues in Psoriasis
Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cro...
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| Published in: | Frontiers in immunology Vol. 10; p. 1507 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
Frontiers Media S.A
28-06-2019
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Antonio La Cava, University of California, Los Angeles, United States; Katriina Vuolteenaho, University of Tampere, Finland This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology Edited by: Oreste Gualillo, Servicio Gallego de Salud, Spain |
| ISSN: | 1664-3224 1664-3224 |
| DOI: | 10.3389/fimmu.2019.01507 |