Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds...

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Published in:Frontiers in oncology Vol. 11; p. 650256
Main Authors: Sarvizadeh, Mahshad, Hasanpour, Omid, Naderi Ghale-Noie, Zari, Mollazadeh, Samaneh, Rezaei, Mohammad, Pourghadamyari, Hossein, Masoud Khooy, Mohammadjaber, Aschner, Michael, Khan, Haroon, Rezaei, Nima, Shojaie, Layla, Mirzaei, Hamed
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 27-04-2021
Subjects:
allicin
chemical structure
gastrointenstinal cancer
natural compounds
Oncology
therapy
gastrointenstinal cancer
natural compounds
allicin
chemical structure
therapy
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Summary:Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the vast majority of them are colorectal or gastric malignancies. Epidemiological evidence confirmed that allium-containing food, such as garlic, reduces the risk of developing malignancies. Among all compounds in garlic, allicin has been most researched, as it contains sulfur and produces many second degradation compounds, such as sulfur dioxide, diallyl sulfide (DAS), diallyl trisulfide (DATS), and diallyl disulfide (DADS) in the presence of enzymatic reactions in gastric juice. These substances have shown anti-inflammatory, antidiabetic, antihypertensive, antifungal, antiviral, antibacterial, and anticancer efficacy, including gastrointestinal (GI) cancers, leukemia, and skin cancers. Herein, we summarize the therapeutic potential of allicin in the treatment of GI cancers.
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This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology
Edited by: Prasanna K. Santhekadur, JSS Academy of Higher Education and Research, India
Reviewed by: Wenxing Chen, Nanjing University of Chinese Medicine, China; Shivendra Vikram Singh, St. Jude Children's Research Hospital, United States
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.650256