PD-L1 Expression Correlated with p53 Expression in Pediatric Glioblastoma Multiforme

• Published in: Brain sciences Vol. 11; no. 2; p. 262
• Main Authors: Litak, Jakub, Grajkowska, Wiesława, Szumiło, Justyna, Krukow, Paweł, Maciejewski, Ryszard, Roliński, Jacek, Grochowski, Cezary
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 19-02-2021; MDPI AG
• Subjects: GBM; PD-L1; pediatric glioblastoma multiforme; PD-L1; pediatric glioblastoma multiforme; GBM
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci11020262

High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and suppression. Eighteen patients with a histopathological diagnosis of pediatric glioblastoma multiforme (GBM, WHO IV) were studied. In total, PD-L1 expression was detected in 8 patients (44%). The molecular aspect of IC and immunotherapy targeted on PD-1/PD-L1 axis in pediatric population may be a promising adjuvant therapy in pediatric glioblastoma multiform treatment, however, this subject requires further investigation.