Mother-to-child transmission of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women with single, dual or triplex infections of human immunodeficiency virus, hepatitis B virus and hepatitis C virus in Nigeria: A systematic review and meta-analysis

• Published in: SAGE Open Medicine Vol. 10; p. 20503121221095411
• Main Authors: Eleje, George Uchenna, Onubogu, Chinyere Ukamaka, Fiebai, Preye Owen, Mbachu, Ikechukwu Innocent, Akaba, Godwin Otuodichinma, Loto, Olabisi Morebise, Usman, Hadiza Abdullahi, Rabiu, Ayyuba, Chibuzor, Moriam Taiwo, Chukwuanukwu, Rebecca Chinyelu, Joe-Ikechebelu, Ngozi Nneka, Nwankwo, Chike Henry, Kalu, Stephen Okoroafor, Ogbuagu, Chukwuanugo Nkemakonam, Chukwurah, Shirley Nneka, Uzochukwu, Chinwe Elizabeth, Oppah, Ijeoma Chioma, Ahmed, Aishat, Egeonu, Richard Obinwanne, Jibuaku, Chiamaka Henrietta, Inuyomi, Samuel Oluwagbenga, Adesoji, Bukola Abimbola, Anyang, Ubong Inyang, Ogwaluonye, Uchenna Chukwunonso, Emeka, Ekene Agatha, Igue, Odion Emmanuel, Okoro, Ogbonna Dennis, Aja, Prince Ogbonnia, Chidozie, Chiamaka Perpetua, Ibrahim, Hadiza Sani, Aliyu, Fatima Ele, Numan, Aisha Ismaila, Omoruyi, Solace Amechi, Umeononihu, Osita Samuel, Okoro, Chukwuemeka Chukwubuikem, Nwaeju, Ifeanyi Kingsley, Onwuegbuna, Arinze Anthony, Umeh, Eric Okechukwu, Nweje, Sussan Ifeyinwa, Eleje, Lydia Ijeoma, Ajuba, Ifeoma Clara, Ikwuka, David Chibuike, Igbodike, Emeka Philip, Chigbo, Chisom God’swill, Ebubedike, Uzoamaka Rufina, Okafor, Chigozie Geoffrey, Obiegbu, Nnaedozie Paul, Yakasai, Ibrahim Adamu, Ezechi, Oliver Chukwujekwu, Ikechebelu, Joseph Ifeanyichukwu
• Format: Book Review Journal Article
• Language: English
• Published: London, England SAGE Publications 2022; Sage Publications Ltd; SAGE Publishing
• Subjects: Confidence intervals; Hepatitis B; Hepatitis C; HIV; Human immunodeficiency virus; Immune system; Infections; Meta-analysis; Pregnancy; Systematic Review; Nigeria; hepatitis C virus; human immunodeficiency virus; Nigeria; infectious diseases; Hepatitis B; mother-to-child transmission
• ISSN: 2050-3121; 2050-3121
• DOI: 10.1177/20503121221095411

Objectives: To systematically review literature and identify mother-to-child transmission rates of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among pregnant women with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria. PRISMA guidelines were employed. Searches were on 19 February 2021 in PubMed, Google Scholar and CINAHL on studies published from 1 February 2001 to 31 January 2021 using keywords: “MTCT,” “dual infection,” “triplex infection,” “HIV,” “HBV,” and “HCV.” Studies that reported mother-to-child transmission rate of at least any of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among pregnant women and their infant pairs with single, dual, or triplex infections of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Nigeria irrespective of publication status or language were eligible. Data were extracted independently by two authors with disagreements resolved by a third author. Meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary mother-to-child transmission rates in terms of percentage with 95% confidence interval. Protocol was prospectively registered in PROSPERO: CRD42020202070. The search identified 849 reports. After screening titles and abstracts, 25 full-text articles were assessed for eligibility and 18 were included for meta-analysis. We identified one ongoing study. Pooled mother-to-child transmission rates were 2.74% (95% confidence interval: 2.48%–2.99%; 5863 participants; 15 studies) and 55.49% (95% confidence interval: 35.93%–75.04%; 433 participants; three studies), among mother–infant pairs with mono-infection of human immunodeficiency virus and hepatitis B virus, respectively, according to meta-analysis. Overall, the studies showed a moderate risk of bias. The pooled rate of mother-to-child transmission of human immunodeficiency virus was 2.74% and hepatitis B virus was 55.49% among mother–infant pairs with mono-infection of HIV and hepatitis B virus, respectively. No data exists on rates of mother-to-child transmission of hepatitis C virus on mono-infection or mother-to-child transmission of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus among mother–infant pairs with dual or triplex infection of HIV, hepatitis B virus and HCV in Nigeria.