Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents

Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents

Cardiovascular disease (CVD) is the largest cause of mortality worldwide, and stress is a significant contributor to the development of CVD. The relationship between acute and chronic stress and CVD is well evidenced. Acute stress can lead to arrhythmias and ischemic injury. However, recent evidence...

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Bibliographic Details
Published in:Frontiers in psychiatry Vol. 7; p. 71
Main Authors: Eisenmann, Eric D, Rorabaugh, Boyd R, Zoladz, Phillip R
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 25-04-2016
Subjects:
Anxiety
cardiovascular
Ischemia
Psychiatry
PTSD
rodent models
stress
PTSD
anxiety
stress
cardiovascular
rodent
ischemia
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Summary:Cardiovascular disease (CVD) is the largest cause of mortality worldwide, and stress is a significant contributor to the development of CVD. The relationship between acute and chronic stress and CVD is well evidenced. Acute stress can lead to arrhythmias and ischemic injury. However, recent evidence in rodent models suggests that acute stress can decrease sensitivity to myocardial ischemia-reperfusion injury (IRI). Conversely, chronic stress is arrhythmogenic and increases sensitivity to myocardial IRI. Few studies have examined the impact of validated animal models of stress-related psychological disorders on the ischemic heart. This review examines the work that has been completed using rat models to study the effects of stress on myocardial sensitivity to ischemic injury. Utilization of animal models of stress-related psychological disorders is critical in the prevention and treatment of cardiovascular disorders in patients experiencing stress-related psychiatric conditions.
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Edited by: Stefan Oskar Reber, University of Ulm, Germany
Specialty section: This article was submitted to Affective Disorders and Psychosomatic Research, a section of the journal Frontiers in Psychiatry
Reviewed by: Tobias Opthof, Academic Medical Center, Netherlands; Angela J. Grippo, Northern Illinois University, USA
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2016.00071