Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the stagin...

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Published in:Frontiers in pharmacology Vol. 8; p. 150
Main Authors: Evola, Francesco R, Costarella, Luciano, Pavone, Vito, Caff, Giuseppe, Cannavò, Luca, Sessa, Andrea, Avondo, Sergio, Sessa, Giuseppe
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 07-04-2017
Subjects:
Pharmacology
chondrosarcoma
Ewing sarcoma
biomarkers
osteosarcoma
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Abstract Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.
AbstractList Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.
Author Caff, Giuseppe
Costarella, Luciano
Sessa, Andrea
Pavone, Vito
Evola, Francesco R
Sessa, Giuseppe
Cannavò, Luca
Avondo, Sergio
AuthorAffiliation Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di Catania Catania, Italy
AuthorAffiliation_xml – name: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di Catania Catania, Italy
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  givenname: Francesco R
  surname: Evola
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– sequence: 2
  givenname: Luciano
  surname: Costarella
  fullname: Costarella, Luciano
  organization: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di CataniaCatania, Italy
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  givenname: Vito
  surname: Pavone
  fullname: Pavone, Vito
  organization: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di CataniaCatania, Italy
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  givenname: Giuseppe
  surname: Caff
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  givenname: Luca
  surname: Cannavò
  fullname: Cannavò, Luca
  organization: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di CataniaCatania, Italy
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  givenname: Andrea
  surname: Sessa
  fullname: Sessa, Andrea
  organization: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di CataniaCatania, Italy
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  givenname: Sergio
  surname: Avondo
  fullname: Avondo, Sergio
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  givenname: Giuseppe
  surname: Sessa
  fullname: Sessa, Giuseppe
  organization: Clinica Ortopedica, Dipartimento di Chirurgia, Azienda Ospedaliera-Universitaria Policlinico Vittorio Emanuele di CataniaCatania, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28439237$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1155/2012/404810
10.1053/jpon.2000.16397
10.18632/oncotarget.398
10.1007/s11626-007-9075-8
10.1007/s11033-008-9378-1
10.1021/pr100480r
10.1007/s00264-011-1208-8
10.1093/carcin/bgq117
10.1007/s10735-011-9370-2
10.1158/1078-0432.CCR-07-0806
10.1002/pbc.21576
10.1158/1078-0432.CCR-10-0558
10.1093/annonc/mdq223
10.1111/j.1600-0463.2009.02583.x
10.1002/cncr.25563
10.1007/s10585-011-9384-x
10.1158/1541-7786.MCR-12-0086
10.1002/cncr.26116
10.1016/j.bone.2010.05.027
10.4149/neo_2010_01_062
10.3760/cma.j.issn.0366-6999.2010.13.028
10.1158/1078-0432.CCR-08-2330
10.1038/onc.2008.484
10.1097/FPC.0b013e32833caa45
10.1007/s12011-009-8382-1
10.1158/0008-5472.CAN-08-3580
10.1016/j.ctrv.2006.05.005
10.1016/j.bbrc.2012.02.110
10.1038/labinvest.2008.98
10.1158/0008-5472.CAN-07-5582
10.1177/030089160809400310
10.2106/JBJS.J.00949
10.1002/path.1723
10.1177/147323000803600518
10.4161/cc.10.19.17734
10.3892/mmr.2012.772
10.1016/j.humpath.2009.05.008
10.3233/CBM-2012-0227
10.1200/JCO.20.3.776
10.4161/cc.7.2.5229
10.1038/labinvest.2008.99
10.1007/s11999-010-1315-7
10.1111/j.1440-1827.2009.02510.x
10.1371/journal.pone.0004932
10.2106/00004623-199605000-00004
10.1016/j.bbrc.2009.07.101
10.1007/978-3-642-21892-7_10
10.1016/j.cancergen.2012.04.001
10.1186/1471-2407-9-17
10.1200/JCO.2003.08.132
10.1089/gtmb.2010.0264
10.1016/j.jmoldx.2011.01.004
10.1053/j.sempedsurg.2005.11.005
10.1016/j.ejca.2008.07.021
10.1016/j.ejca.2009.11.002
10.1158/1078-0432.CCR-10-3069
10.1007/s13277-010-0146-1
10.1158/1078-0432.CCR-10-1417
10.1002/jor.21178
10.1023/A:1008391103132
10.1158/0008-5472.CAN-09-4333
10.2106/JBJS.H.00717
10.1007/978-1-4419-0284-9_15
10.1002/cncr.26488
10.1080/09553000802195349
10.1016/S0140-6736(07)60781-8
10.1002/path.2913
10.1177/030089160909500307
10.1002/ijc.24665
10.1158/1535-7163.MCT-11-0096
10.1097/PAI.0b013e3181fd6697
10.1016/S0031-3955(05)70540-X
10.1097/00003086-198011000-00013
10.1111/j.1365-2613.2010.00749.x
10.1371/journal.pone.0041401
10.3892/or.2012.1687
10.1586/14737140.6.7.1075
10.1002/jso.22077
10.1158/0008-5472.CAN-07-6152
10.1186/1746-1596-7-84
10.1016/j.jmoldx.2010.11.020
10.1089/hyb.2007.0519
10.3892/ijo.2012.1426
10.1007/s11864-008-0057-1
10.1158/1078-0432.CCR-08-2184
10.1590/S1807-59322011000900015
10.1309/AJCP6V4YPFBOCYXG
10.1517/17425240903280422
10.1186/2045-3329-2-9
10.5435/00124635-200908000-00005
10.1038/onc.2011.317
10.1186/1471-2407-10-169
10.1038/modpathol.2009.120
10.1001/jama.1920.02620100016007
10.1002/pbc.22864
10.1158/1541-7786.MCR-11-0347
10.3727/096504009789954627
10.1186/2045-3329-1-5
10.1016/j.canlet.2009.09.018
10.1007/s12253-010-9358-3
10.1186/1746-1596-5-69
10.1053/ejso.1999.0741
10.3892/ol.2011.526
10.1186/1476-4598-9-17
10.1097/MPH.0b013e31816e238c
10.1096/fj.10-179036
10.1007/s00428-011-1138-2
10.1002/jso.21140
10.1007/s10517-009-0710-0
10.3949/ccjm.75.10.739
ContentType Journal Article
Copyright Copyright © 2017 Evola, Costarella, Pavone, Caff, Cannavò, Sessa, Avondo and Sessa. 2017 Evola, Costarella, Pavone, Caff, Cannavò, Sessa, Avondo and Sessa
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Keywords chondrosarcoma
Ewing sarcoma
biomarkers
osteosarcoma
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Edited by: Giovanni Li Volti, University of Catania, Italy
Reviewed by: Vincenzo Bramanti, Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Italy; Francesco Cappello, University of Palermo, Italy
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
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References 19082467 - Oncol Rep. 2009 Jan;21(1):229-35
21926473 - Cell Cycle. 2011 Oct 1;10(19):3397-408
12180616 - Iowa Orthop J. 2002;22:75-80
20066901 - Oncol Res. 2009;18(2-3):117-25
18701473 - Cancer Res. 2008 Aug 15;68(16):6507-15
18722108 - Eur J Cancer. 2008 Nov;44(16):2518-25
11821461 - J Clin Oncol. 2002 Feb 1;20(3):776-90
20555083 - Ann Oncol. 2010 May;21 Suppl 5:v204-13
22297550 - Cancer Biomark. 2011-2012;10(1):35-41
22870217 - PLoS One. 2012;7(8):e41401
22577336 - Sarcoma. 2012;2012:404810
19734846 - Mod Pathol. 2009 Nov;22(11):1489-98
19632201 - Biochem Biophys Res Commun. 2009 Oct 9;388(1):35-40
18449804 - Curr Treat Options Oncol. 2008 Feb;9(1):67-80
20577141 - Pharmacogenet Genomics. 2010 Aug;20(8):507-15
20132188 - APMIS. 2010 Mar;118(3):222-9
21267687 - Pathol Oncol Res. 2011 Sep;17 (3):619-25
22587902 - Clin Sarcoma Res. 2012 Mar 23;2:9
22009261 - Cancer. 2012 Apr 15;118(8):2106-16
21458381 - J Mol Diagn. 2011 May;13(3):289-96
20525755 - Clin Cancer Res. 2010 Jul 15;16(14):3769-78
18661375 - Int J Radiat Biol. 2008 Jul;84(7):591-601
22740963 - Oncol Lett. 2012 Mar;3(3):621-624
20004565 - Eur J Cancer. 2010 Feb;46(3):616-24
21866554 - J Surg Oncol. 2012 Mar;105(3):235-43
18705402 - Tumori. 2008 May-Jun;94(3):347-50
20660237 - J Bone Joint Surg Am. 2010 Jul 21;92(8):1738-46
22682618 - Cancer Genet. 2012 May;205(5):193-204
22340557 - Chin Med J (Engl). 2012 Jan;125(2):262-9
21370409 - Pediatr Blood Cancer. 2011 May;56(5):771-6
21385990 - FASEB J. 2011 Jun;25(6):2022-30
20333492 - Clin Orthop Relat Res. 2010 Jul;468(7):2000-2
20442286 - Cancer Res. 2010 May 15;70(10 ):4015-23
21887539 - Virchows Arch. 2011 Oct;459(4):409-14
22809428 - Diagn Pathol. 2012 Jul 18;7:84
19144156 - BMC Cancer. 2009 Jan 14;9:17
10718181 - Eur J Surg Oncol. 2000 Feb;26(1):53-60
20973064 - J Orthop Res. 2010 Dec;28(12):1621-5
18797196 - J Pediatr Hematol Oncol. 2008 Jul;30(7):507-12
20806347 - Cancer. 2011 Jan 1;117(1):207-17
19305498 - PLoS One. 2009;4(3):e4932
9286295 - Pediatr Clin North Am. 1997 Aug;44(4):973-89
21495021 - Cancer. 2011 Nov 1;117(21):4925-38
19652033 - J Am Acad Orthop Surg. 2009 Aug;17(8):515-27
22179165 - Clinics (Sao Paulo). 2011;66(9):1591-6
20580954 - Bone. 2010 Aug;47(2):445-54
16458843 - Semin Pediatr Surg. 2006 Feb;15(1):25-9
21598255 - J Pathol. 2011 Jul;224(3):334-43
20102637 - Mol Cancer. 2010 Jan 26;9:17
21084965 - Appl Immunohistochem Mol Morphol. 2011 May;19(3):233-8
22228819 - Mol Cancer Res. 2012 Mar;10(3):454-68
22613849 - Clin Sarcoma Res. 2011 Jul 25;1(1):5
19151750 - Oncogene. 2009 Mar 5;28(9):1280-4
21207222 - Tumour Biol. 2011 Jun;32(3):515-26
18838962 - Lab Invest. 2008 Dec;88(12):1264-77
22390931 - Biochem Biophys Res Commun. 2012 Mar 23;419(4):801-8
19896763 - Cancer Lett. 2010 May 1;291(1):31-8
18931939 - Mol Biol Rep. 2009 Jan;36(1):153-8
18792969 - J Surg Oncol. 2008 Nov 1;98(6):415-20
22394629 - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Mar;28(3):237-9
18256529 - Cell Cycle. 2008 Jan 15;7(2):250-6
16860938 - Cancer Treat Rev. 2006 Oct;32(6):423-36
21822310 - Oncogene. 2012 Mar 8;31(10 ):1287-98
19336518 - Clin Cancer Res. 2009 Apr 15;15(8):2685-94
20213397 - Cancer Treat Res. 2009;152:289-308
20530236 - Carcinogenesis. 2010 Aug;31(8):1400-4
22042095 - J Mol Histol. 2012 Feb;43(1):63-70
19390788 - Biol Trace Elem Res. 2011 Dec;144(1-3):1-5
22258776 - J Bone Joint Surg Am. 2011 Dec 21;93(24):2294-302
21047978 - Clin Cancer Res. 2011 Jan 1;17 (1):56-66
20429896 - BMC Cancer. 2010 Apr 29;10:169
12743156 - J Clin Oncol. 2003 May 15;21(10):2011-8
19695675 - Hum Pathol. 2009 Oct;40(10):1479-86
18939390 - Cleve Clin J Med. 2008 Oct;75(10):739-50
20819644 - Chin Med J (Engl). 2010 Jul;123(13):1768-73
11063515 - J Pediatr Oncol Nurs. 2000 Oct;17(4):207-28
8642021 - J Bone Joint Surg Am. 1996 May;78(5):656-63
19544560 - Int J Cancer. 2009 Dec 1;125(11):2586-94
18421709 - Pediatr Blood Cancer. 2008 Aug;51(2):222-7
22293903 - Mol Med Rep. 2012 Apr;5(4):1033-6
18158779 - Hybridoma (Larchmt). 2007 Dec;26(6):355-62
20027339 - Bull Exp Biol Med. 2009 Aug;148(2):246-9
21078112 - Int J Exp Pathol. 2010 Oct;91(5):387-93
19688969 - Tumori. 2009 May-Jun;95(3):311-6
18247100 - In Vitro Cell Dev Biol Anim. 2008 Mar-Apr;44(3-4):87-95
21467162 - Clin Cancer Res. 2011 May 1;17(9):2900-7
20690664 - J Proteome Res. 2010 Sep 3;9(9):4861-8
21249357 - Int Orthop. 2011 Oct;35(10):1529-36
18831895 - J Int Med Res. 2008 Sep-Oct;36(5):1008-14
21461590 - Clin Exp Metastasis. 2011 Jun;28(5):493-503
20942912 - Diagn Pathol. 2010 Oct 13;5:69
22202598 - Oncotarget. 2011 Dec;2(12):970-5
18339860 - Cancer Res. 2008 Mar 15;68(6):1797-808
22485251 - Int J Oncol. 2012 Jul;41(1):153-60
21453059 - Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):503-6
22723308 - Mol Cancer Res. 2012 Aug;10(8):1098-108
19584295 - Cancer Res. 2009 Jul 15;69(14 ):5648-55
18838963 - Lab Invest. 2008 Dec;88(12):1291-302
7449206 - Clin Orthop Relat Res. 1980 Nov-Dec;(153):106-20
18245529 - Clin Cancer Res. 2008 Feb 1;14(3):701-9
21458383 - J Mol Diagn. 2011 May;13(3):313-24
21666078 - Mol Cancer Ther. 2011 Aug;10(8):1337-45
19318479 - Clin Cancer Res. 2009 Apr 1;15(7):2259-68
20403045 - Pathol Int. 2010 Mar;60(3):193-202
15685701 - J Pathol. 2005 Mar;205(4):476-82
9789613 - Ann Oncol. 1998 Aug;9(8):893-9
17512859 - Lancet. 2007 May 19;369(9574):1742-57
19895174 - Neoplasma. 2010;57(1):62-7
22307377 - Recent Results Cancer Res. 2012;192:197-223
19761419 - Expert Opin Drug Deliv. 2009 Dec;6(12):1311-21
16831079 - Expert Rev Anticancer Ther. 2006 Jul;6(7):1075-85
22338054 - Am J Clin Pathol. 2012 Mar;137(3):423-8
18606058 - Ai Zheng. 2008 Jul;27(7):677-84
22344865 - Oncol Rep. 2012 May;27(5):1592-8
Yao (B114) 2009; 21
Howlader (B44) 2002
Meyers (B69) 1997; 44
Rozeman (B83) 2005; 205
Zambo (B117) 2012; 27
Shen (B92) 2012; 28
Duan (B23) 2011; 10
Messerschmitt (B68) 2009; 17
Tirino (B99) 2011; 25
Yang (B113) 2012; 41
Lee (B54) 2011; 19
Wang (B103) 2010; 47
Liang (B58) 2012; 7
Nathan (B72) 2009; 36
Papachristou (B74) 2008; 44
Bacci (B6) 2008; 98
Xu (B108) 2010; 28
Won (B106) 2009; 95
Bielack (B11) 2008; 9
Ariizumi (B2) 2010; 60
Szuhai (B97) 2009; 15
Zenmyo (B118) 2010; 5
Hallor (B38) 2009; 15
Aryee (B3) 2010; 70
Harting (B41) 2006; 15
Amary (B1) 2011; 224
Sandhu (B87) 2011; 144
Mackintosh (B65) 2012; 31
Sharili (B91) 2011; 32
Bielack (B10) 2005
Savola (B89) 2009; 14
Yang (B110) 2010; 123
Levings (B55) 2009; 69
Li (B57) 2011; 117
Enneking (B25) 1980; 153
Folio (B29) 2011; 10
Yasuda (B115) 2012; 3
Zhang (B119) 2010; 9
Link (B59) 1989
Potikyan (B79) 2008; 88
Fletcher (B28) 2002
Erkizan (B26) 2011; 10
Luo (B63) 2008; 88
Posthuma DeBoer (B78) 2011; 28
Pradelli (B80) 2009; 125
Yalçin (B109) 2008; 51
Sun (B95) 2010; 9
Lu (B62) 2012; 5
He (B42) 2009; 388
Wang (B102) 2012; 105
Mirabello (B70) 2010; 31
Saini (B85) 2012; 7
Douglas (B22) 2008; 68
Cintra (B18) 2011; 66
Kager (B52) 2003; 21
Shimizu (B93) 2012; 10
Zhao (B120) 2008; 27
Perbal (B76) 2009; 40
Singer (B94) 2008; 75
Funovics (B32) 2011; 35
Salinas-Souza (B86) 2010; 20
Joerger (B51) 2012; 192
Ham (B39) 2000; 26
Kaseta (B53) 2007; 26
Yang (B111) 2010; 291
Ash (B4) 2011; 17
Eccles (B24) 2007; 369
Bielack (B13) 2002; 20
Zuffa (B121) 2008; 84
Babkina (B5) 2009; 148
Robin (B81) 2012; 10
Bielack (B12) 2009; 152
Chou (B17) 2006; 6
Gillette (B34) 2008; 44
Hancock (B40) 2008; 15
Yang (B112) 2011; 117
Guan (B35) 2009; 18
Guillon (B36) 2009; 4
Lockwood (B60) 2011; 13
Szuhai (B96) 2012; 205
Tan (B98) 2012; 419
Vural (B100) 2011; 17
Fletcher (B27) 2002
Huang (B46) 2012; 118
Bachmaier (B7) 2009; 28
Bennani-Baiti (B9) 2010; 16
Meijer (B67) 2011; 1
Weber (B104) 2002; 22
Nakagawa (B71) 2010; 92
Broders (B14) 1920; 74
De Nigris (B20) 2008; 68
Jawad (B49) 2010; 468
Pedrini (B75) 2011; 93
Hu (B45) 2010; 10
Yu (B116) 2010; 118
Chandhanarat (B15) 2012; 2012
Hogendoorn (B43) 2010; 21(Suppl. 5)
Schrage (B90) 2010; 46
Savitskaya (B88) 2012; 23
Gamberi (B33) 2011; 13
Mankin (B66) 1996; 78
Perbal (B77) 2008; 14
Longhi (B61) 2006; 32
Wei (B105) 2008; 36
Nunez (B73) 2012; 137
Jin (B50) 2012; 125
Jamil (B48) 2010; 91
Lewis (B56) 2003; 22
Cooper (B19) 2011; 17
Rodriguez (B82) 2008; 30
Machado (B64) 2011; 459
Do (B21) 2008; 94
Franke (B30) 2011; 56
Baumhoer (B8) 2011; 2
Wang (B101) 2011; 15
Fuchs (B31) 1998; 9
Woodgate (B107) 2000; 17
Chen (B16) 2012; 43
Rozeman (B84) 2009; 22
Guo (B37) 2010; 57
Hughes (B47) 2009; 6
References_xml – volume: 125
  start-page: 262
  year: 2012
  ident: B50
  article-title: Decreased expression of serum gelsolin in patients with osteosarcoma.
  publication-title: Chin. Med. J.
  contributor:
    fullname: Jin
– volume: 2012
  issue: 404810
  year: 2012
  ident: B15
  article-title: MAPK/ERK signaling in osteosarcomas, Ewing sarcomas and chondrosarcomas: therapeutic implications and future directions.
  publication-title: Sarcoma
  doi: 10.1155/2012/404810
  contributor:
    fullname: Chandhanarat
– volume: 17
  start-page: 207
  year: 2000
  ident: B107
  article-title: A critical review of qualitative research related to children’s experiences with cancer.
  publication-title: J. Pediatr. Oncol. Nurs.
  doi: 10.1053/jpon.2000.16397
  contributor:
    fullname: Woodgate
– volume: 2
  start-page: 970
  year: 2011
  ident: B8
  article-title: CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.398
  contributor:
    fullname: Baumhoer
– volume: 44
  start-page: 87
  year: 2008
  ident: B34
  article-title: Establishment and characterization of OS 99-1, a cell line derived from a highly aggressive primary humanosteosarcoma.
  publication-title: In vitro Cell. Dev. Biol. Anim.
  doi: 10.1007/s11626-007-9075-8
  contributor:
    fullname: Gillette
– volume: 36
  start-page: 153
  year: 2009
  ident: B72
  article-title: Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.
  publication-title: Mol. Biol. Rep.
  doi: 10.1007/s11033-008-9378-1
  contributor:
    fullname: Nathan
– volume: 9
  start-page: 4861
  year: 2010
  ident: B119
  article-title: Serum and urinary metabonomic study of human osteosarcoma.
  publication-title: J. Proteome Res.
  doi: 10.1021/pr100480r
  contributor:
    fullname: Zhang
– volume: 35
  start-page: 1529
  year: 2011
  ident: B32
  article-title: Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma.
  publication-title: Int. Orthop.
  doi: 10.1007/s00264-011-1208-8
  contributor:
    fullname: Funovics
– volume: 31
  start-page: 1400
  year: 2010
  ident: B70
  article-title: National osteosarcoma etiology study group. Genetic variation at chromosome 8q24 in osteosarcoma cases and controls.
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgq117
  contributor:
    fullname: Mirabello
– volume: 43
  start-page: 63
  year: 2012
  ident: B16
  article-title: The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis.
  publication-title: J. Mol. Histol.
  doi: 10.1007/s10735-011-9370-2
  contributor:
    fullname: Chen
– volume: 14
  start-page: 701
  year: 2008
  ident: B77
  article-title: Prognostic value of CCN3 in osteosarcoma.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-07-0806
  contributor:
    fullname: Perbal
– volume: 51
  start-page: 222
  year: 2008
  ident: B109
  article-title: C-erbB-2 expression and prognostic significance in osteosarcoma.
  publication-title: Pediatr. Blood Cancer
  doi: 10.1002/pbc.21576
  contributor:
    fullname: Yalçin
– volume: 16
  start-page: 3769
  year: 2010
  ident: B9
  article-title: Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing’s.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-10-0558
  contributor:
    fullname: Bennani-Baiti
– volume: 21(Suppl. 5)
  start-page: v204
  year: 2010
  ident: B43
  article-title: Bone sarcomas: ESMO clinical practice guidelines fordiagnosis, treatment and follow-up.
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdq223
  contributor:
    fullname: Hogendoorn
– volume: 118
  start-page: 222
  year: 2010
  ident: B116
  article-title: Mitotic arrest defective protein 2 expression abnormality and its clinicopathologic significance in human osteosarcoma.
  publication-title: APMIS
  doi: 10.1111/j.1600-0463.2009.02583.x
  contributor:
    fullname: Yu
– volume: 117
  start-page: 207
  year: 2011
  ident: B57
  article-title: Elevated expression of CXC chemochines in pediatric osteosarcoma patients.
  publication-title: Cancer
  doi: 10.1002/cncr.25563
  contributor:
    fullname: Li
– volume: 28
  start-page: 493
  year: 2011
  ident: B78
  article-title: Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature.
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-011-9384-x
  contributor:
    fullname: Posthuma DeBoer
– volume: 10
  start-page: 1098
  year: 2012
  ident: B81
  article-title: EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708 resulting in increased cell survival and chemoresistance.
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-12-0086
  contributor:
    fullname: Robin
– volume: 117
  start-page: 4925
  year: 2011
  ident: B112
  article-title: Genetic amplification of the Vascular Endothelial Growth Factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma.
  publication-title: Cancer
  doi: 10.1002/cncr.26116
  contributor:
    fullname: Yang
– volume: 47
  start-page: 445
  year: 2010
  ident: B103
  article-title: Functional and biological analysis of Bcl-xL expression in human osteosarcoma.
  publication-title: Bone
  doi: 10.1016/j.bone.2010.05.027
  contributor:
    fullname: Wang
– volume: 57
  start-page: 62
  year: 2010
  ident: B37
  article-title: Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma.
  publication-title: Neoplasma
  doi: 10.4149/neo_2010_01_062
  contributor:
    fullname: Guo
– volume: 123
  start-page: 1768
  year: 2010
  ident: B110
  article-title: Arsenic trioxide up-regulates Fas expression in human osteosarcoma cells.
  publication-title: Chin. Med. J.
  doi: 10.3760/cma.j.issn.0366-6999.2010.13.028
  contributor:
    fullname: Yang
– volume: 15
  start-page: 2685
  year: 2009
  ident: B38
  article-title: Genomic profiling of chondrosarcoma: chromosomal patterns in central and peripheral tumors.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-2330
  contributor:
    fullname: Hallor
– volume: 28
  start-page: 1280
  year: 2009
  ident: B7
  article-title: O-GlcNAcylation is involved in the transcriptional activity of EWS-FLI1 in Ewing’s sarcoma.
  publication-title: Oncogene
  doi: 10.1038/onc.2008.484
  contributor:
    fullname: Bachmaier
– year: 1989
  ident: B59
  article-title: “Pediatric oncology: osteosarcoma,” in
  publication-title: Principles and Practice of Pediatric Oncology
  contributor:
    fullname: Link
– volume: 20
  start-page: 507
  year: 2010
  ident: B86
  article-title: Glutathione S-transferase polymorphisms in osteosarcoma patients.
  publication-title: Pharmacogenet. Genomics
  doi: 10.1097/FPC.0b013e32833caa45
  contributor:
    fullname: Salinas-Souza
– volume: 144
  start-page: 1
  year: 2011
  ident: B87
  article-title: Serum fluoride and sialic acid levels in osteosarcoma.
  publication-title: Biol. Trace Elem. Res.
  doi: 10.1007/s12011-009-8382-1
  contributor:
    fullname: Sandhu
– volume: 69
  start-page: 5648
  year: 2009
  ident: B55
  article-title: Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-3580
  contributor:
    fullname: Levings
– volume: 32
  start-page: 423
  year: 2006
  ident: B61
  article-title: Primary bone osteosarcoma in the pediatric age: state of the art.
  publication-title: Cancer Treat. Rev.
  doi: 10.1016/j.ctrv.2006.05.005
  contributor:
    fullname: Longhi
– volume: 419
  start-page: 801
  year: 2012
  ident: B98
  article-title: Expression and prognostic relevance of PRAME in primary osteosarcoma.
  publication-title: Biochem. Biophys. Res. Comm.
  doi: 10.1016/j.bbrc.2012.02.110
  contributor:
    fullname: Tan
– volume: 21
  start-page: 229
  year: 2009
  ident: B114
  article-title: The expression of Crm1 is associated with prognosis in human osteosarcoma.
  publication-title: Oncol. Rep.
  contributor:
    fullname: Yao
– volume: 88
  start-page: 1264
  year: 2008
  ident: B63
  article-title: Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects.
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.2008.98
  contributor:
    fullname: Luo
– volume: 68
  start-page: 1797
  year: 2008
  ident: B20
  article-title: Deletion of yin yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-5582
  contributor:
    fullname: De Nigris
– volume: 22
  start-page: 75
  year: 2002
  ident: B104
  article-title: Low-grade/dedifferentiated/high-grade chondrosarcoma: a case of histological and biological progression.
  publication-title: Iowa Orthop. J.
  contributor:
    fullname: Weber
– volume: 94
  start-page: 347
  year: 2008
  ident: B21
  article-title: Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma.
  publication-title: Tumori
  doi: 10.1177/030089160809400310
  contributor:
    fullname: Do
– volume: 93
  start-page: 2294
  year: 2011
  ident: B75
  article-title: Genotype-phenotype correlation study in 529 patients with multiple hereditary exostoses: Identification of “Protective” and “Risk” Factors.
  publication-title: J. Bone Joint Surg. Am.
  doi: 10.2106/JBJS.J.00949
  contributor:
    fullname: Pedrini
– volume: 205
  start-page: 476
  issue: 4
  year: 2005
  ident: B83
  article-title: Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.
  publication-title: J. Pathol.
  doi: 10.1002/path.1723
  contributor:
    fullname: Rozeman
– volume: 36
  start-page: 1008
  year: 2008
  ident: B105
  article-title: Expression of c-kit protein and mutational status of the c-kit gene in osteosarcoma and their clinicopathological significance.
  publication-title: J. Int. Med. Res.
  doi: 10.1177/147323000803600518
  contributor:
    fullname: Wei
– volume: 10
  start-page: 3397
  year: 2011
  ident: B26
  article-title: Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.
  publication-title: Cell Cycle
  doi: 10.4161/cc.10.19.17734
  contributor:
    fullname: Erkizan
– volume: 5
  start-page: 1033
  year: 2012
  ident: B62
  article-title: Expression of WNT-5a and ROR2 correlates with disease severity in osteosarcoma.
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2012.772
  contributor:
    fullname: Lu
– volume: 40
  start-page: 1479
  year: 2009
  ident: B76
  article-title: Prognostic value of CCN3 in osteosarcoma.
  publication-title: Hum. Pathol.
  doi: 10.1016/j.humpath.2009.05.008
  contributor:
    fullname: Perbal
– volume: 10
  start-page: 35
  year: 2011
  ident: B29
  article-title: Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival.
  publication-title: Cancer Biomark.
  doi: 10.3233/CBM-2012-0227
  contributor:
    fullname: Folio
– volume: 20
  start-page: 776
  year: 2002
  ident: B13
  article-title: Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.20.3.776
  contributor:
    fullname: Bielack
– volume: 15
  start-page: 250
  year: 2008
  ident: B40
  article-title: A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature.
  publication-title: Cell Cycle
  doi: 10.4161/cc.7.2.5229
  contributor:
    fullname: Hancock
– volume: 88
  start-page: 1291
  year: 2008
  ident: B79
  article-title: Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing’s family tumors.
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.2008.99
  contributor:
    fullname: Potikyan
– volume: 468
  start-page: 2000
  year: 2010
  ident: B49
  article-title: Enneking classification: benign and malignant tumors of the musculoskeletal system.
  publication-title: Clin. Orthop. Relat. Res.
  doi: 10.1007/s11999-010-1315-7
  contributor:
    fullname: Jawad
– year: 2002
  ident: B28
  article-title: “Pathology and genetics of tumours of soft tissue and bone,” in
  publication-title: WHO Classification of Tumours
  contributor:
    fullname: Fletcher
– volume: 60
  start-page: 193
  year: 2010
  ident: B2
  article-title: Expression of podoplanin in human bone and bone tumors: new marker of osteogenic and chondrogenic bone tumors.
  publication-title: Pathol. Int.
  doi: 10.1111/j.1440-1827.2009.02510.x
  contributor:
    fullname: Ariizumi
– volume: 4
  issue: e4932
  year: 2009
  ident: B36
  article-title: The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function.
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0004932
  contributor:
    fullname: Guillon
– volume: 78
  start-page: 656
  year: 1996
  ident: B66
  article-title: The hazards of the biopsy, revisited. Members of the musculoskeletal tumor society.
  publication-title: J. Bone Joint Surg. Am.
  doi: 10.2106/00004623-199605000-00004
  contributor:
    fullname: Mankin
– volume: 388
  start-page: 35
  year: 2009
  ident: B42
  article-title: Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples.
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.07.101
  contributor:
    fullname: He
– volume: 192
  start-page: 197
  year: 2012
  ident: B51
  article-title: Diagnostic and prognostic use of bone turnover markers.
  publication-title: Recent Results Cancer Res.
  doi: 10.1007/978-3-642-21892-7_10
  contributor:
    fullname: Joerger
– volume: 205
  start-page: 193
  year: 2012
  ident: B96
  article-title: Molecular pathology and its diagnosticuse in bone tumors.
  publication-title: Can. Genet.
  doi: 10.1016/j.cancergen.2012.04.001
  contributor:
    fullname: Szuhai
– volume: 14
  issue: 17
  year: 2009
  ident: B89
  article-title: Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors.
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-9-17
  contributor:
    fullname: Savola
– volume: 21
  start-page: 2011
  year: 2003
  ident: B52
  article-title: Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2003.08.132
  contributor:
    fullname: Kager
– volume: 15
  start-page: 503
  year: 2011
  ident: B101
  article-title: Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma.
  publication-title: Genet. Test. Mol. Biomarkers
  doi: 10.1089/gtmb.2010.0264
  contributor:
    fullname: Wang
– volume: 13
  start-page: 313
  year: 2011
  ident: B33
  article-title: Molecular diagnosis in Ewing family tumors. The Rizzoli experience—222 consecutive cases in four years.
  publication-title: J. Mol. Diagn.
  doi: 10.1016/j.jmoldx.2011.01.004
  contributor:
    fullname: Gamberi
– volume: 15
  start-page: 25
  year: 2006
  ident: B41
  article-title: Management of osteosarcoma pulmonary metastases.
  publication-title: Semin. Pediatr. Surg.
  doi: 10.1053/j.sempedsurg.2005.11.005
  contributor:
    fullname: Harting
– volume: 44
  start-page: 2518
  year: 2008
  ident: B74
  article-title: Expression of integrin-linked kinase and its binding partners inchondrosarcoma: association with prognostic significance.
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2008.07.021
  contributor:
    fullname: Papachristou
– volume: 46
  start-page: 616
  year: 2010
  ident: B90
  article-title: COX-2 expression in chondrosarcoma: a role for celecoxibtreatment?
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2009.11.002
  contributor:
    fullname: Schrage
– volume: 17
  start-page: 2900
  year: 2011
  ident: B4
  article-title: Excellent prognosis in a subset of patients with ewing sarcoma identified at diagnosis by CD56 using flow cytometry.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-10-3069
  contributor:
    fullname: Ash
– volume: 32
  start-page: 515
  year: 2011
  ident: B91
  article-title: Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy.
  publication-title: Tumor Biol.
  doi: 10.1007/s13277-010-0146-1
  contributor:
    fullname: Sharili
– volume: 17
  start-page: 56
  year: 2011
  ident: B19
  article-title: Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the children’s oncology group.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-10-1417
  contributor:
    fullname: Cooper
– volume: 28
  start-page: 1621
  year: 2010
  ident: B108
  article-title: Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma.
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.21178
  contributor:
    fullname: Xu
– volume: 9
  start-page: 893
  year: 1998
  ident: B31
  article-title: Long-term results of the co-operative German-Austrian-swiss osteosarcoma study group’s protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs.
  publication-title: Ann. Oncol.
  doi: 10.1023/A:1008391103132
  contributor:
    fullname: Fuchs
– volume: 70
  start-page: 4015
  year: 2010
  ident: B3
  article-title: Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of ewing’s sarcoma cells in vitro.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-09-4333
  contributor:
    fullname: Aryee
– volume: 92
  start-page: 1738
  year: 2010
  ident: B71
  article-title: Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis.
  publication-title: J. Bone Joint Surg. Am.
  doi: 10.2106/JBJS.H.00717
  contributor:
    fullname: Nakagawa
– volume: 152
  start-page: 289
  year: 2009
  ident: B12
  article-title: Osteosarcoma: the COSS experience.
  publication-title: Cancer Treat. Res.
  doi: 10.1007/978-1-4419-0284-9_15
  contributor:
    fullname: Bielack
– volume: 118
  start-page: 2106
  year: 2012
  ident: B46
  article-title: CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor in Ewing sarcoma cells.
  publication-title: Cancer
  doi: 10.1002/cncr.26488
  contributor:
    fullname: Huang
– volume: 84
  start-page: 591
  year: 2008
  ident: B121
  article-title: P53 oncosuppressor influences selection of genomic imbalances in response to ionizing radiations in human osteosarcoma cell line SAOS-2.
  publication-title: Int. J. Radiat. Biol.
  doi: 10.1080/09553000802195349
  contributor:
    fullname: Zuffa
– volume: 369
  start-page: 1742
  year: 2007
  ident: B24
  article-title: Metastasis: recent discoveries and novel treatment strategies.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)60781-8
  contributor:
    fullname: Eccles
– volume: 224
  start-page: 334
  year: 2011
  ident: B1
  article-title: IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.
  publication-title: J. Pathol.
  doi: 10.1002/path.2913
  contributor:
    fullname: Amary
– year: 2002
  ident: B27
  article-title: “Pathology and genetics of tumours of soft tissue and bone,” in
  publication-title: WHO Classification of Tumours,
  contributor:
    fullname: Fletcher
– volume: 95
  start-page: 311
  year: 2009
  ident: B106
  article-title: Prognostic implication of immunohistochemical Runx2 expression in osteosarcoma.
  publication-title: Tumori
  doi: 10.1177/030089160909500307
  contributor:
    fullname: Won
– volume: 125
  start-page: 2586
  year: 2009
  ident: B80
  article-title: Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.24665
  contributor:
    fullname: Pradelli
– volume: 10
  start-page: 1337
  year: 2011
  ident: B23
  article-title: MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration.
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-11-0096
  contributor:
    fullname: Duan
– volume: 19
  start-page: 233
  year: 2011
  ident: B54
  article-title: FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma.
  publication-title: Appl. Immunohistochem. Mol. Morphol.
  doi: 10.1097/PAI.0b013e3181fd6697
  contributor:
    fullname: Lee
– volume: 44
  start-page: 973
  year: 1997
  ident: B69
  article-title: Osteosarcoma.
  publication-title: Pediatr. Clin. North Am.
  doi: 10.1016/S0031-3955(05)70540-X
  contributor:
    fullname: Meyers
– volume: 153
  start-page: 106
  year: 1980
  ident: B25
  article-title: A system for the surgical staging of musculoskeletal sarcoma.
  publication-title: Clin. Orthop. Relat. Res.
  doi: 10.1097/00003086-198011000-00013
  contributor:
    fullname: Enneking
– volume: 91
  start-page: 387
  year: 2010
  ident: B48
  article-title: Therapeutic molecular targets in human chondrosarcoma.
  publication-title: Int. J. Exp. Pathol.
  doi: 10.1111/j.1365-2613.2010.00749.x
  contributor:
    fullname: Jamil
– volume: 7
  issue: e41401
  year: 2012
  ident: B85
  article-title: Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0041401
  contributor:
    fullname: Saini
– volume: 27
  start-page: 1592
  year: 2012
  ident: B117
  article-title: Nestin expression in high-grade osteosarcomas and its clinical significance.
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2012.1687
  contributor:
    fullname: Zambo
– volume: 6
  start-page: 1075
  year: 2006
  ident: B17
  article-title: Chemotherapy resistance in osteosarcoma: current challenges and future directions.
  publication-title: Expert Rev. Anticancer Ther.
  doi: 10.1586/14737140.6.7.1075
  contributor:
    fullname: Chou
– volume: 105
  start-page: 235
  year: 2012
  ident: B102
  article-title: Increased expression of insulin-like growth factor-1 receptor is correlated with tumor metastasis and prognosis in patients with osteosarcoma.
  publication-title: J. Surg. Oncol.
  doi: 10.1002/jso.22077
  contributor:
    fullname: Wang
– volume: 68
  start-page: 6507
  year: 2008
  ident: B22
  article-title: BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression.
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-6152
  contributor:
    fullname: Douglas
– volume: 7
  issue: 84
  year: 2012
  ident: B58
  article-title: Expression of Aurora Kinase A and B in chondrosarcoma and its relationshipwith the prognosis.
  publication-title: Diagn. Pathol.
  doi: 10.1186/1746-1596-7-84
  contributor:
    fullname: Liang
– volume: 13
  start-page: 289
  year: 2011
  ident: B60
  article-title: Cyclin E1 is amplified and overexpressed in osteosarcoma.
  publication-title: J. Mol. Diagn.
  doi: 10.1016/j.jmoldx.2010.11.020
  contributor:
    fullname: Lockwood
– volume: 26
  start-page: 355
  year: 2007
  ident: B53
  article-title: Prognostic value of bax, cytochrome C, and caspase-8 protein expression in primary osteosarcoma.
  publication-title: Hybridoma
  doi: 10.1089/hyb.2007.0519
  contributor:
    fullname: Kaseta
– volume: 41
  start-page: 153
  year: 2012
  ident: B113
  article-title: All-trans retinoic acid inhibits tumor growth of human osteosarcoma by activating Smad signaling-induced osteogenic differentiation.
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2012.1426
  contributor:
    fullname: Yang
– volume: 9
  start-page: 67
  year: 2008
  ident: B11
  article-title: Bone tumors in adolescents and young adults.
  publication-title: Curr. Treat. Options Oncol.
  doi: 10.1007/s11864-008-0057-1
  contributor:
    fullname: Bielack
– volume: 28
  start-page: 237
  year: 2012
  ident: B92
  article-title: Expression and localization of ArgBP2 in osteosarcoma MG-63 cells.
  publication-title: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
  contributor:
    fullname: Shen
– volume: 15
  start-page: 2259
  year: 2009
  ident: B97
  article-title: The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology.
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-2184
  contributor:
    fullname: Szuhai
– volume: 66
  start-page: 1591
  year: 2011
  ident: B18
  article-title: Analysis of angiogenic factors and cyclooxygenase-2expression in cartilaginous tumors – clinical and histological correlation.
  publication-title: Clinics
  doi: 10.1590/S1807-59322011000900015
  contributor:
    fullname: Cintra
– volume: 137
  start-page: 423
  year: 2012
  ident: B73
  article-title: CD138 (syndecan-1) expression in bone-forming tumors.
  publication-title: Am. J. Clin. Pathol.
  doi: 10.1309/AJCP6V4YPFBOCYXG
  contributor:
    fullname: Nunez
– volume: 6
  start-page: 1311
  year: 2009
  ident: B47
  article-title: Strategies for the targeted delivery of therapeutics for osteosarcoma.
  publication-title: Expert Opin. Drug Deliv.
  doi: 10.1517/17425240903280422
  contributor:
    fullname: Hughes
– volume: 23
  issue: 9
  year: 2012
  ident: B88
  article-title: Serum tumor markers in pediatric osteosarcoma: a summary review.
  publication-title: Clin. Sarcoma Res.
  doi: 10.1186/2045-3329-2-9
  contributor:
    fullname: Savitskaya
– volume: 17
  start-page: 515
  year: 2009
  ident: B68
  article-title: Osteosarcoma.
  publication-title: J. Am. Acad. Orthop. Surg.
  doi: 10.5435/00124635-200908000-00005
  contributor:
    fullname: Messerschmitt
– year: 2002
  ident: B44
  publication-title: In SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations).
  contributor:
    fullname: Howlader
– volume: 31
  start-page: 1287
  year: 2012
  ident: B65
  article-title: 1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
  publication-title: Oncogene
  doi: 10.1038/onc.2011.317
  contributor:
    fullname: Mackintosh
– volume: 10
  issue: 169
  year: 2010
  ident: B45
  article-title: Association between TGFBR1∗6A and osteosarcoma: a Chinese case-control study.
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-10-169
  contributor:
    fullname: Hu
– volume: 27
  start-page: 677
  year: 2008
  ident: B120
  article-title: Expression and localization of hnRNP A2/B1 during differentiation of human osteosarcoma MG-63 cells induced by HMBA.
  publication-title: Ai Zheng
  contributor:
    fullname: Zhao
– year: 2005
  ident: B10
  article-title: Osteosarcoma
  publication-title: Cancer in Children: Clinical Management
  contributor:
    fullname: Bielack
– volume: 22
  start-page: 1489
  year: 2009
  ident: B84
  article-title: Dedifferentiated peripheral chondrosarcomas: regulation of EXT-downstream molecules and differentiation-related genes.
  publication-title: Mod. Pathol.
  doi: 10.1038/modpathol.2009.120
  contributor:
    fullname: Rozeman
– volume: 74
  start-page: 656
  year: 1920
  ident: B14
  article-title: Squamous cellepithelioma of the lip: a study of 537 cases.
  publication-title: JAMA
  doi: 10.1001/jama.1920.02620100016007
  contributor:
    fullname: Broders
– volume: 22
  issue: 816
  year: 2003
  ident: B56
  article-title: Chemotherapy at standard or increased dose intensity in patients with operable osteosarcoma of the extremity: a randomised controlled trial conducted by the European Osteosarcoma Intergroup.
  publication-title: Proc. Am. Soc. Clin. Oncol.
  contributor:
    fullname: Lewis
– volume: 56
  start-page: 771
  year: 2011
  ident: B30
  article-title: Solitary skeletal osteosarcoma recurrence. Findings from the cooperative osteosarcoma study group.
  publication-title: Pediatr. Blood Cancer
  doi: 10.1002/pbc.22864
  contributor:
    fullname: Franke
– volume: 10
  start-page: 454
  year: 2012
  ident: B93
  article-title: Fibroblast growth factor-2 is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma.
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-11-0347
  contributor:
    fullname: Shimizu
– volume: 18
  start-page: 117
  year: 2009
  ident: B35
  article-title: VEGF165 promotes the osteolytic bone destruction of Ewing’s sarcoma tumors by upregulating RANKL.
  publication-title: Oncol. Res.
  doi: 10.3727/096504009789954627
  contributor:
    fullname: Guan
– volume: 1
  issue: 5
  year: 2011
  ident: B67
  article-title: Expression of aromatase and estrogen receptoralpha in chondrosarcoma, but no beneficial effectof inhibiting estrogen signaling both in vitro and in vivo.
  publication-title: Clin. Sarcoma Res.
  doi: 10.1186/2045-3329-1-5
  contributor:
    fullname: Meijer
– volume: 291
  start-page: 31
  year: 2010
  ident: B111
  article-title: Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma.
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2009.09.018
  contributor:
    fullname: Yang
– volume: 17
  start-page: 619
  year: 2011
  ident: B100
  article-title: The evaluation of CD99 immunoreactivity and EWS/FLI1 translocation by fluorescence in situ hybridization in central PNETs and Ewing’s sarcoma.
  publication-title: Pathol. Oncol. Res.
  doi: 10.1007/s12253-010-9358-3
  contributor:
    fullname: Vural
– volume: 5
  issue: 69
  year: 2010
  ident: B118
  article-title: Gadd45b expression in chondrosarcoma: a pilotstudy for diagnostic and biological implications in histological grading.
  publication-title: Diagn. Pathol.
  doi: 10.1186/1746-1596-5-69
  contributor:
    fullname: Zenmyo
– volume: 26
  start-page: 53
  year: 2000
  ident: B39
  article-title: Osteosarcoma of the pelvis – oncological results of 40 patients registered by The Netherlands Committee on Bone Tumours.
  publication-title: Eur. J. Surg. Oncol.
  doi: 10.1053/ejso.1999.0741
  contributor:
    fullname: Ham
– volume: 3
  start-page: 621
  year: 2012
  ident: B115
  article-title: Extraskeletal myxoid chondrosarcoma of the thigh with a t(9;17) translocation.
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2011.526
  contributor:
    fullname: Yasuda
– volume: 9
  issue: 17
  year: 2010
  ident: B95
  article-title: CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression.
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-17
  contributor:
    fullname: Sun
– volume: 30
  start-page: 507
  year: 2008
  ident: B82
  article-title: COX-2 expression correlates with survival in patients with osteosarcoma lung metastases.
  publication-title: J. Pediatr. Hematol. Oncol.
  doi: 10.1097/MPH.0b013e31816e238c
  contributor:
    fullname: Rodriguez
– volume: 25
  start-page: 2023
  year: 2011
  ident: B99
  article-title: Human primary bone sarcomas contain CD133 cancerstem cells displaying high tumorigenicity in vivo.
  publication-title: FASEB J.
  doi: 10.1096/fj.10-179036
  contributor:
    fullname: Tirino
– volume: 459
  start-page: 409
  year: 2011
  ident: B64
  article-title: Epithelial marker expression does not rule out a diagnosis of Ewing’s sarcoma family of tumours.
  publication-title: Virchows Arch.
  doi: 10.1007/s00428-011-1138-2
  contributor:
    fullname: Machado
– volume: 98
  issue: 415420
  year: 2008
  ident: B6
  article-title: High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions.
  publication-title: J. Surg. Oncol.
  doi: 10.1002/jso.21140
  contributor:
    fullname: Bacci
– volume: 148
  start-page: 246
  year: 2009
  ident: B5
  article-title: Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas.
  publication-title: Bull. Exp. Biol. Med.
  doi: 10.1007/s10517-009-0710-0
  contributor:
    fullname: Babkina
– volume: 75
  start-page: 739
  year: 2008
  ident: B94
  article-title: Using biochemical markers of bone turnover in clinical practice.
  publication-title: Cleve. Clin. J. Med.
  doi: 10.3949/ccjm.75.10.739
  contributor:
    fullname: Singer
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Snippet Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made...
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SubjectTerms Pharmacology
Title Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma
URI https://www.ncbi.nlm.nih.gov/pubmed/28439237
https://search.proquest.com/docview/1891891086
https://pubmed.ncbi.nlm.nih.gov/PMC5383728
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