Predicting Chronic Subdural Hematoma Resolution and Time to Resolution Following Surgical Evacuation

• Published in: Frontiers in neurology Vol. 11; p. 677
• Main Authors: Chang, Cory L, Sim, Justin L, Delgardo, Mychael W, Ruan, Diana T, Connolly, Jr, E Sander
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14-07-2020
• Subjects: chronic subdural hematoma; hematoma recurrence; hematoma resolution; Neurology; subdural hematoma; surgical evacuation; traumatic brain injury; subdural hematoma; burr hole; hematoma recurrence; craniotomy; surgical evacuation; traumatic brain injury; chronic subdural hematoma; hematoma resolution
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2020.00677

Growing evidence suggests that chronic subdural hematoma (CSDH) may have long-term adverse effects even after surgical evacuation. Hematoma recurrence is commonly reported as a short-term, postoperative outcome measure for CSDH, but other measures such as hematoma resolution may provide better insight regarding mechanisms behind longer-term sequelae. This study aims to characterize postoperative resolution times and identify predictors for this relatively unexplored metric.
Consecutive cases (
= 122) of burr hole evacuation for CSDH by a single neurosurgeon at Columbia University Irving Medical Center from 2000 to 2019 were retrospectively identified. Patient characteristics, presenting factors, and date of hematoma resolution were abstracted from the electronic health record. Outcome measures included CSDH resolution at 6 months, surgery-to-resolution time, and inpatient mortality. Univariate and multivariate analyses were performed to determine predictors of outcome measures.
Hematoma resolution at 6 months was observed in 58 patients (47.5%), and median surgery-to-resolution time was 161 days (IQR: 85-367). Heavy drinking was predictive of non-resolution at 6 months and longer surgery-to-resolution time, while increased age was predictive of non-resolution at 6 months. Antiplatelet agent resumption was associated with non-resolution at 6 months and longer surgery-to-resolution time on univariate analysis but was not significant on multivariate analysis.
Postoperative resolution times for most CSDHs are on the order of several months to a year, and delayed resolution is linked to heavy drinking and advanced age. Subsequent prospective studies are needed to directly assess the utility of hematoma resolution as a potential metric for long-term functional and cognitive outcomes of CSDH.