Autophagy in Viral Development and Progression of Cancer

Autophagy in Viral Development and Progression of Cancer

Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy...

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Bibliographic Details
Published in:Frontiers in oncology Vol. 11; p. 603224
Main Authors: Suares, Alejandra, Medina, María Victoria, Coso, Omar
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 08-03-2021
Subjects:
autophagy
cancer cells
cell death
cell survival
human diseases
Oncology
oncoviruses
cancer cells
autophagy
cell survival
human diseases
oncoviruses
cell death
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Summary:Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells.
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Reviewed by: Alfredo Criollo, University of Chile, Chile; Priyanka Gupta, University of Alabama at Birmingham, United States
Edited by: Daniel Hector Grasso, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.603224