A long-term retrospective study of patients with biopsy-proven cryptogenic organizing pneumonia

• Published in: Chronic respiratory disease Vol. 16; p. 1479973119853829
• Main Authors: Zhou, Ying, Wang, Lei, Huang, Mei, Ding, Jingjing, Jiang, Hanyi, Zhou, Kefeng, Meng, Fanqing, Xiao, Yonglong, Cai, Hourong, Dai, Jinghong
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01-01-2019; Sage Publications Ltd
• Subjects: Antibiotics; Bacterial infections; Clinical outcomes; Original Paper; Pneumonia; Steroids; corticosteroids; relapse; Cryptogenic organizing pneumonia; risk factor; outcome
• ISSN: 1479-9731; 1479-9723; 1479-9731
• DOI: 10.1177/1479973119853829

Cryptogenic organizing pneumonia (COP) is characterized by good response to corticosteroids, but frequent relapses after reduction or cessation of treatment are noted. The incidence, risk factors of relapse, and long-term outcomes of patients with COP remain undetermined. Patients with COP from September 2010 to December 2017 were enrolled. Hospital and office records were used as data sources. Clinical information, lab examinations, chest radiographs, treatment courses, and follow-up data were collected. Relapse group was defined as worsening of clinical manifestations in combination with progression of radiographic abnormalities in the absence of identified causes. Eighty-seven patients with COP were enrolled. Of them, 73 patients were treated with corticosteroids with relapse rate yielding 31.5% (23 of 73). Eleven patients were treated with macrolides and none of them relapsed. Fever was more common (65.2% vs. 32.0%, p = 0.004), C-reactive protein (CRP) was higher (31.5 ± 39.4 mg/L vs. 17.5 ± 32.2 mg/L, p = 0.038), and diffusion capacity for carbon monoxide (DLCO) % predicted was lower (45.9 ± 14.2% vs. 57.6 ± 18.5%, p = 0.050) in relapse group compared to nonrelapse group. Four patients who presented with organizing pneumonia (OP) as the first manifestation were ultimately diagnosed with OP secondary to autoimmune disease in follow-up. We showed relapse was common in COP patients treated with corticosteroids, but the prognosis was favorable. Fever, elevated CRP, and a reduced DLCO were related to relapse. As OP may not always be cryptogenic, a careful follow-up should be programmed to diagnose the underlying systemic disease.