Accumulation of Tau Protein, Metabolism and Perfusion-Application and Efficacy of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Imaging in the Examination of Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS)

• Published in: Frontiers in neurology Vol. 10; p. 101
• Main Authors: Alster, Piotr, Madetko, Natalia Katarzyna, Koziorowski, Dariusz Mariusz, Królicki, Leszek, Budrewicz, Sławomir, Friedman, Andrzej
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14-02-2019
• Subjects: corticobasal syndrome (CBS); neuroimaging; Neurology; PET - positron emission tomography; progressive supranucelar palsy; SPECT and PET imaging; PET - positron emission tomography; progressive supranucelar palsy; SPECT and PET imaging; corticobasal syndrome (CBS); neuroimaging
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2019.00101

Neuroimaging in the context of examining atypical parkinsonian tauopathies is an evolving matter. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) bring tools, which may be reasonable in supplementary examination, however cannot be interpreted as a gold standard for correct diagnosis. The review presents advantages and limitations of tau radiotracers in PET, metabolic PET and perfusion SPECT. The aim of this paper is to highlight the possibilities and boundaries in the supplementary examination of tauopathic parkinsonian syndromes.