Antidiarrheal activity of extracts from Maytenus gonoclada and inhibition of Dengue virus by lupeol

• Published in: Anais da Academia Brasileira de Ciências Vol. 89; no. 3; pp. 1555 - 1564
• Main Authors: Silva, Fernando C, Rodrigues, Vanessa G, Duarte, Lucienir P, Lula, Ivana S, Sinisterra, Ruben D, Vieira-Filho, Sidney A, Rodrigues, Rodrigo A L, Kroon, Erna G, Oliveira, Patrícia L, Farias, Luiz M, Magalhães, Paula P, Silva, Grácia D F
• Format: Journal Article
• Language: English
• Published: Brazil Academia Brasileira de Ciências 01-07-2017
• Subjects: Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antidiarrheal; Antidiarrheals - isolation & purification; Antidiarrheals - pharmacology; Antiviral Activity; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Celastraceae; Cell Line; Dengue Virus - drug effects; Maytenus - chemistry; Maytenus - classification; MULTIDISCIPLINARY SCIENCES; Pentacyclic Triterpene; Pentacyclic Triterpenes - isolation & purification; Pentacyclic Triterpenes - pharmacology; Plant Extracts - pharmacology; Pentacyclic Triterpene; Antiviral Activity; Celastraceae; Antidiarrheal
• ISSN: 0001-3765; 1678-2690; 1678-2690
• DOI: 10.1590/0001-3765201720160046

Diarrhea is an infectious disease caused by bacterial, virus, or protozoan, and dengue is caused by virus, included among the neglected diseases in several underdeveloped and developing countries, with an urgent demand for new drugs. Considering the antidiarrheal potential of species of Maytenus genus, a phytochemical investigation followed by antibacterial activity test with extracts of branches and heartwood and bark of roots from Maytenus gonoclada were conducted. Moreover, due the frequency of isolation of lupeol from Maytenus genus the antiviral activity against Dengue virus and cytotoxicity of lupeol and its complex with β-cyclodextrins were also tested. The results indicated the bioactivity of ethyl acetate extract from branches and ethanol extract from heartwood of roots of M. gonoclada against diarrheagenic bacteria. The lupeol showed potent activity against Dengue virus and low cytotoxicity in LLC-MK2 cells, but its complex with β-cyclodextrin was inactive. Considering the importance of novel and selective antiviral drug candidates the results seem to be promising.