Intracranial Osteosarcoma After Radiosurgery Case Report

• Published in: Neurologia medico-chirurgica Vol. 44; no. 1; pp. 29 - 32
• Main Authors: SANNO, Naoko, HAYASHI, Shinkichi, SHIMURA, Toshiro, MAEDA, Shotaro, TERAMOTO, Akira
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 01-01-2004
• Subjects: brain neoplasm; Female; Follow-Up Studies; Frontal Lobe - pathology; Frontal Lobe - surgery; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms - diagnosis; Meningeal Neoplasms - surgery; Meningioma - diagnosis; Meningioma - surgery; Middle Aged; Neoplasms, Radiation-Induced - diagnosis; Neoplasms, Radiation-Induced - pathology; Neoplasms, Radiation-Induced - surgery; Neoplasms, Second Primary - diagnosis; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - surgery; osteosarcoma; Osteosarcoma - diagnosis; Osteosarcoma - pathology; Osteosarcoma - surgery; Parietal Lobe - pathology; Parietal Lobe - surgery; Postoperative Complications - diagnosis; Postoperative Complications - pathology; Postoperative Complications - surgery; Radiosurgery - adverse effects; radiosurgery-induced neoplasm; Reoperation; Tomography, X-Ray Computed
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.44.29

A 56-year-old woman presented with an intracranial osteosarcoma at the site of previous radiosurgery, manifesting as sudden onset of headache and left hemiparesis with aphasia. She had a previous history of stereotactic radiosurgery for an intracranial tumor under a diagnosis of falx meningioma. Computed tomography showed intratumoral and peritumoral hemorrhage at the right parietofrontal region. Gross total resection of the tumor with hematoma was performed. The histological diagnosis was osteosarcoma. Sarcomatous change is a rare complication of radiotherapy. This case illustrates that osteosarcoma may develop years after radiosurgery for benign brain neoplasm.