Effect of cytokines on anticryptococcal activity of human microglial cells

The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervo...

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Bibliographic Details
Published in:	Clinical and diagnostic laboratory immunology Vol. 5; no. 3; pp. 410 - 411
Main Authors:	Lipovsky, M M, Juliana, A E, Gekker, G, Hu, S, Hoepelman, A I, Peterson, P K
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-05-1998
Series:	Note
Subjects:	Cryptococcus neoformans - growth & development Cryptococcus neoformans - immunology Culture Media Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans Interferon-alpha - pharmacology Microglia - immunology Microglia - microbiology
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Summary:	The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Present address: Division of Infectious Diseases and AIDS, Department of Medicine, University Hospital Utrecht, Utrecht, The Netherlands. Corresponding author. Mailing address: University of Minnesota Medical School, Minneapolis, MN 55415. Phone: (612) 347-2877. Fax: (612) 904-4299. E-mail: peter137@maroon.tc.umn.edu.
ISSN:	1071-412X 1098-6588
DOI:	10.1128/cdli.5.3.410-411.1998