Use of trans-Sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection

trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and...

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Bibliographic Details
Published in:	Clinical and diagnostic laboratory immunology Vol. 5; no. 2; pp. 254 - 255
Main Authors:	Leguizamón, M S, Russomando, G, Rojas de Arias, A, Samudio, M, Cabral, M, González-Cappa, S M, Frasch, A C, Campetella, O
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-03-1998
Series:	Note
Subjects:	Animals Chagas Disease - blood Humans Neuraminidase Sensitivity and Specificity Serologic Tests - methods Trypanosoma cruzi - isolation & purification
Online Access:	Get full text
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Summary:	trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Corresponding author. Mailing address: Instituto de Investigaciones Biotecnológicas, Universidad Nacional de Gral. San Martín, Casilla de Correo 30, 1650 San Martín, Buenos Aires, Argentina. Phone: 54 1 752-0021. Fax: 54 1 752-9639. E-mail: oscar@inti.gov.ar.
ISSN:	1071-412X 1098-6588
DOI:	10.1128/cdli.5.2.254-255.1998