Non‐steroidal anti‐inflammatory drugs, aspirin and newly diagnosed colitis: a case–control study

• Published in: Alimentary pharmacology & therapeutics Vol. 17; no. 6; pp. 817 - 825
• Main Authors: Gleeson, M. H., Davis, A. J. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-03-2003; Blackwell
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Aspirin - adverse effects; Biological and medical sciences; Case-Control Studies; Colitis - chemically induced; Drug toxicity and drugs side effects treatment; Female; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Toxicity: digestive system; Human; Prostaglandin-endoperoxide synthase; Enzyme; Toxicity; Enzyme inhibitor; Acetylsalicylic acid; Case control study; Epidemiology; Non steroidal antiinflammatory agent; Digestive diseases; Intestinal disease; Oxidoreductases; Colitis; Salicylates
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1046/j.1365-2036.2003.01519.x

Summary
Background : There have been a number of reports of colitis following exposure to non‐steroidal anti‐inflammatory drugs (NSAIDs) and salicylates.
Aim : To conduct a case–control analysis of new cases of colitis, with particular reference to the usage of NSAIDs and salicylates prior to the development of the disease.
Methods : One hundred and five consecutive new cases of colitis presenting to a single gastroenterologist were questioned about their recent usage of NSAIDs and salicylates. For comparison, the frequency of usage of these compounds was studied in two groups of 105 age‐ and sex‐matched controls taken from hospitalin‐patients and community cases attending the Accident and Emergency Department.
Results : Of the 105 cases of colitis studied, 78 patients (74%) had been taking NSAIDs or salicylates prior to or during the development of their disease. By comparison, 20% of community controls were using NSAIDs or salicylates (P < 0.001) and 30% of hospital in‐patients were taking these compounds (P < 0.001). Comparison of these frequencies with those of the colitis group gave odds ratios of 9.1 (4.5, 21.9) with the community controls and 6.2 (3.2, 13.5) with the hospital controls.
Conclusions : In new patients presenting with colitis, there is a significantly high frequency of antecedent exposure to NSAIDs or salicylates, supporting the concept that these agents may be important in the pathogenesis of colitis.