Study of the major essential oil compounds of Coriandrum sativum against Acinetobacter baumannii and the effect of linalool on adhesion, biofilms and quorum sensing

• Published in: Biofouling (Chur, Switzerland) Vol. 32; no. 2; pp. 155 - 165
• Main Authors: Alves, Susana, Duarte, Andreia, Sousa, Sónia, Domingues, Fernanda C.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-01-2016; Taylor & Francis Ltd
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - drug effects; Acinetobacter baumannii - pathogenicity; Acinetobacter baumannii - physiology; Adhesion; Adhesion tests; Adhesiveness - drug effects; Animals; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibacterial materials; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; biofilm; Biofilms; Biofilms - drug effects; Coriandrum; Coriandrum sativum; Detection; essential oil of Coriandrum sativum; Essential oils; Hospitals; Humans; Linalool; Microbial Sensitivity Tests; Minimum inhibitory concentration; Monoterpenes - pharmacology; Oil; Oils, Volatile - pharmacology; Pathogens; Plankton - drug effects; Plankton - physiology; Planktonic cells; quorum sensing; Quorum Sensing - drug effects; Surface chemistry; essential oil of Coriandrum sativum; Acinetobacter baumannii; quorum sensing; adhesion; linalool; biofilm
• ISSN: 0892-7014; 1029-2454
• DOI: 10.1080/08927014.2015.1133810

Acinetobacter baumannii is a pathogen that has the ability to adhere to surfaces in the hospital environment and to form biofilms which are increasingly resistant to antimicrobial agents. The aim of this work was to study the antimicrobial activity of the major oil compounds of Coriandrum sativum against A. baumannii. The effect of linalool on planktonic cells and biofilms of A. baumannii on different surfaces, as well as its effect on adhesion and quorum sensing was evaluated. From all the compounds evaluated, linalool was the compound with the best antibacterial activity, with minimum inhibitory concentration values between 2 and 8 μl ml
−1
. Linalool also inhibited biofilm formation and dispersed established biofilms of A. baumannii, changed the adhesion of A. baumannii to surfaces and interfered with the quorum- sensing system. Thus, linalool could be a promising antimicrobial agent for controlling planktonic cells and biofilms of A. baumannii.