Leptin effects on food and water intake in lines of chickens selected for high or low body weight

• Published in: Physiology & behavior Vol. 84; no. 3; pp. 459 - 464
• Main Authors: Kuo, Alice Y., Cline, Mark A., Werner, Elizabeth, Siegel, Paul B., Denbow, D. Michael
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 16-03-2005
• Subjects: Animals; Body Weight - drug effects; Body Weight - genetics; Brain - drug effects; Chickens; Chickens - genetics; Dose-Response Relationship, Drug; Drinking - drug effects; Eating - drug effects; Food intake; Human recombinant leptin; Humans; Injections, Intraventricular; Intracerebroventricular; Leptin - pharmacology; Male; Receptors, Cell Surface - drug effects; Receptors, Leptin; Recombinant Proteins - pharmacology; Selection, Genetic; Water intake; Water intake; Intracerebroventricular; Food intake; Chickens; Human recombinant leptin
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2005.01.014

There is an association between autonomic nervous system output and obesity. The sympathetic nervous system stimulates lipid metabolism and regulates food intake and, hence, body weight. Leptin, produced by adipocytes in proportion to their size, has been shown to directly stimulate the satiety center. In the experiment reported here, food and water intake were compared after intracerebroventricular administration of human recombinant leptin to lines of chickens that had undergone divergent selection for over 45 generations from a common White Rock base population for high (HWS) or low (LWS) body weight at 8 weeks-of-age. Leptin caused a linear decrease in food intake in chickens from the LWS line whereas no effect was observed in those from the HWS line. The HWS chickens tended to have reduced water intake post leptin administration. Others reported that leptin decreased food intake in both broiler and Leghorn chickens. Leptin concentration in the central nervous system may not contribute directly to the difference of body weight between HWS and LWS chickens.