Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atheroscler...

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Bibliographic Details
Published in:Journal of the American Heart Association Vol. 13; no. 7; p. e031617
Main Authors: Fine, Keenan S, Wilkins, John T, Sawicki, Konrad T
Format: Journal Article
Language:English
Published: England John Wiley and Sons Inc 02-04-2024
Wiley
Subjects:
biochemistry
cardiovascular disease
Contemporary Review
Contemporary Reviews
epidemiologic studies
inflammation
metabolism
epidemiologic studies
cardiovascular disease
metabolism
inflammation
biochemistry
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Summary:Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure. In this review, we provide a detailed overview of BCAA metabolism, focus on molecular mechanisms linking disrupted BCAA homeostasis with cardiometabolic disease, summarize the evidence from observational and interventional studies investigating associations between circulating BCAAs and cardiometabolic disease, and offer valuable insights into the potential for BCAA manipulation as a novel therapeutic strategy for cardiometabolic disease.
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This article was sent to Yen‐Hung Lin, MD, PhD, Associate Editor, for review by expert referees, editorial decision, and final disposition.
For Sources of Funding and Disclosures, see page 10.
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.123.031617