Primary Carcinosarcoma of the Skin: Report of a Case and Review of the Literature

• Published in: Dermatologic surgery Vol. 25; no. 6; pp. 498 - 500
• Main Authors: Brown, Tricia J., Tschen, Jaime A.
• Format: Journal Article
• Language: English
• Published: Boston, MA, USA Blackwell Science Inc 01-06-1999; Blackwell
• Subjects: Aged; Biological and medical sciences; Carcinosarcoma - pathology; Dermatology; Humans; Male; Medical sciences; Skin Neoplasms - pathology; Tumors of the skin and soft tissue. Premalignant lesions; Human; Case study; Skin disease; Skin; Malignant tumor; Elderly; Spindle cell carcinoma
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1046/j.1524-4725.1999.08219.x

Background. Carcinosarcoma is a biphasic tumor composed of intimately admixed epithelial and mesenchymal elements, both of which are malignant. Primary cutaneous involvement is extremely rare. Therefore it has been difficult to characterize the clinical course of carcinosarcoma of the skin.
Objective. To describe a further case of carcinosarcoma of the skin and to provide a review of the literature.
Methods. The clinical records of the patient and histopathology of the neoplasm are reviewed. In addition, the results of all previously reported cases of carcinosarcoma of the skin are compiled for reexamination.
Results. After complete excision of the carcinosarcoma, the patient shows no evidence of disease for 9 months. Long‐term follow‐up is needed because of the risk of recurrence or metastasis that may occur with this neoplasm.
Conclusion. Carcinosarcoma of the skin appears to be associated with a good prognosis when compared with similar tumors located elsewhere. Metastasis (with or without documented mortality) has been reported in 3 of 16 patients (16.7%). Death from local disease has been reported in one additional patient (6.3%). However, further cases with long‐term follow‐up are needed in order to better understand the nature of this cutaneous neoplasm.