Psychosis in Parkinson’s Disease: A Lesson from Genetics

Psychosis in Parkinson’s Disease: A Lesson from Genetics

Psychosis in Parkinson’s disease (PDP) represents a common and debilitating condition that complicates Parkinson’s disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of prese...

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Bibliographic Details
Published in:Genes Vol. 13; no. 6; p. 1099
Main Authors: Angelopoulou, Efthalia, Bougea, Anastasia, Papageorgiou, Sokratis G, Villa, Chiara
Format: Journal Article
Language:English
Published: Basel MDPI AG 20-06-2022
MDPI
Subjects:
Aging
Alzheimer's disease
Autophagy
Cognitive ability
Complications and side effects
Development and progression
Dopamine
Genes
Genetic aspects
Hallucinations
Health risk assessment
Kinases
Mitochondria
Mortality
Movement disorders
Mutation
Neurodegenerative diseases
Neurosciences
Oxidative stress
Parkinson's disease
Pathogenesis
Pathophysiology
Proteins
Psychoses
Psychosis
Quality of life
Review
Risk factors
Sensory integration
Vision
Greece
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Summary:Psychosis in Parkinson’s disease (PDP) represents a common and debilitating condition that complicates Parkinson’s disease (PD), mainly in the later stages. The spectrum of psychotic symptoms are heterogeneous, ranging from minor phenomena of mild illusions, passage hallucinations and sense of presence to severe psychosis consisting of visual hallucinations (and rarely, auditory and tactile or gustatory) and paranoid delusions. PDP is associated with increased caregiver stress, poorer quality of life for patients and carers, reduced survival and risk of institutionalization with a significant burden on the healthcare system. Although several risk factors for PDP development have been identified, such as aging, sleep disturbances, long history of PD, cognitive impairment, depression and visual disorders, the pathophysiology of psychosis in PD is complex and still insufficiently clarified. Additionally, several drugs used to treat PD can aggravate or even precipitate PDP. Herein, we reviewed and critically analyzed recent studies exploring the genetic architecture of psychosis in PD in order to further understand the pathophysiology of PDP, the risk factors as well as the most suitable therapeutic strategies.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes13061099