The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland

• Published in: Nuclear medicine and molecular imaging Vol. 55; no. 1; pp. 27 - 30
• Main Authors: Lim, Andreas, Budiawan, Hendra, Kartamihardja, A. Hussein S.
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01-02-2021; Springer Nature B.V; 대한핵의학회
• Subjects: Cardiology; Imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original; Original Article; Orthopedics; Radiology; Receptors; Thyroid gland; 방사선과학; Radioactive iodine; H2-receptor antagonist; Thyroid gland 24-h uptake
• ISSN: 1869-3474; 1869-3482
• DOI: 10.1007/s13139-020-00676-1

Purpose
The aim of this study was to determine the influence of H2RAs to the 24-h I-131 uptake in the thyroid gland.
Material and Methods
A prospective study with quasi-experimental pre- and post-study design was done. Subjects with normal fT4 level who fulfilled the inclusion criteria were selected. All subjects received 0.2 mCi of I-131 orally, and the thyroid uptake calculations were performed at 24 h later. The same procedure was performed 4 weeks later. All of the subjects were asked to consume H2RAs 1 h before the administration of I-131 of the second procedure. Both 24-h thyroid uptakes were statistically analysed.
Results
A total of 14 subjects were enrolled in this study. Most of them were women (78%) with an average age of 37.6 years old (range: 20–55). This study showed a median of 24-h thyroid uptake of I-131 before and after H2-receptor antagonist of 20.6% (range: 11.1–57.8%) and 16.7% (range: 8.1–39.4%) respectively.
Conclusion
H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.