IL-10 production by CD4 effector T cells: a mechanism for self-regulation

The development of Th1 lymphocytes is essential for cell-mediated immunity and resistance against intracellular pathogens. However, if left unregulated, the same response can cause serious damage to host tissues and lead to mortality. A number of different paracrine regulatory mechanisms involving d...

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Bibliographic Details
Published in:	Mucosal immunology Vol. 3; no. 3; pp. 239 - 246
Main Authors:	Jankovic, D, Kugler, D G, Sher, A
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-05-2010 Elsevier Limited
Subjects:	631/45/127/1213 692/698/1543/1565/1597/554/1898 692/699/255/1715 Allergology Animals Antibodies Autocrine Communication - immunology Biomedical and Life Sciences Biomedicine Gastroenterology Humans Immunity, Cellular - immunology Immunology Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-10 - immunology Interleukin-10 - metabolism Paracrine Communication - immunology review Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology Toxoplasma - immunology Toxoplasmosis - immunology Toxoplasmosis - metabolism Toxoplasmosis - pathology
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Summary:	The development of Th1 lymphocytes is essential for cell-mediated immunity and resistance against intracellular pathogens. However, if left unregulated, the same response can cause serious damage to host tissues and lead to mortality. A number of different paracrine regulatory mechanisms involving distinct myeloid and lymphoid subpopulations have been implicated in controlling excessive secretion of inflammatory cytokines by Th1 cells. Much of this work has focused on interleukin (IL)-10, a cytokine with broad anti-inflammatory properties, one of which is to counteract the function of Th1 lymphocytes. While studying the role of IL-10 in regulating immunopathology during infection with the intracellular parasite Toxoplasma gondii , we discovered that the host-protective IL-10 derives in an autocrine manner from conventional interferon-γ (IFN-γ)-producing T-bet + Foxp3 neg Th1 cells. In the following review, we will discuss these findings that support the general concept that production of IL-10 is an important self-regulatory function of CD4 + T lymphocytes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1933-0219 1935-3456
DOI:	10.1038/mi.2010.8