Adiponectin and leptin gene polymorphisms in patients with post-transplant diabetes mellitus

• Published in: Pharmacogenomics Vol. 16; no. 11; pp. 1243 - 1252
• Main Authors: Romanowski, Maciej, Dziedziejko, Violetta, Maciejewska-Karlowska, Agnieszka, Sawczuk, Marek, Safranow, Krzysztof, Domanski, Leszek, Pawlik, Andrzej
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01-07-2015
• Subjects: adiponectin; Adiponectin - genetics; Adult; Alleles; calcineurin inhibitors; Complications and side effects; Cyclosporine - therapeutic use; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diabetes Mellitus - etiology; Diabetes Mellitus - genetics; Female; Genetic aspects; Genetic polymorphisms; graft; Health aspects; Humans; Immunosuppressive Agents - therapeutic use; kidney; Kidney transplantation; Kidney Transplantation - adverse effects; leptin; Leptin - genetics; Male; Middle Aged; polymorphism; Polymorphism, Genetic - genetics; post-transplant diabetes mellitus; Postoperative Complications - epidemiology; Postoperative Complications - genetics; Risk; Risk factors; Tacrolimus - therapeutic use; adiponectin; kidney; graft; post-transplant diabetes mellitus; polymorphism; leptin; calcineurin inhibitors
• ISSN: 1462-2416; 1744-8042
• DOI: 10.2217/pgs.15.71

Post-transplant diabetes mellitus (PTDM) is a common metabolic complication after organ transplantation and may be associated with the use of calcineurin inhibitors (tacrolimus and cyclosporine). Leptin and adiponectin are adipokines and play an important role in the regulation of insulin secretion as well as glucose and lipid metabolism.
The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and development of PTDM.
The study included 323 patients who received kidney transplants and were treated with calcineurin inhibitors (tacrolimus or cyclosporine).
The association between adiponectin and leptin gene polymorphisms and PTDM was studied in three models of Cox regression analysis - additive, dominant and recessive. In these three models, the
rs2167270 gene polymorphism was statistically significantly associated with increased risk of PTDM. The association between the
rs2167270 polymorphism and PTDM was confirmed by multivariate regression analysis.
: The results of our study suggest an association between the leptin rs2167270 gene A allele and PTDM.
Original submitted 27 February 2015; Revision submitted 22 May 2015