The association between healthy eating index-2015 with anthropometric, cardiometabolic and hepatic indices among patients with non-alcoholic fatty liver disease

• Published in: BMC gastroenterology Vol. 24; no. 1; p. 159
• Main Authors: Hosseini, Seyed Ahmad, Shayesteh, Ali Akbar, Hashemi, Seyed Jalal, Rahimi, Zahra, Saki, Nader, Bavi Behbahani, Hossein, Cheraghian, Bahman, Alipour, Meysam
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10-05-2024; BioMed Central; BMC
• Subjects: Adipose tissue; Adult; Aged; Analysis; Anthropometry; Body mass index; Cardiometabolic Risk Factors; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cholesterol; Cross-Sectional Studies; Diabetes; Diet; Diet, Healthy; Energy; Energy intake; Fatty acids; Fatty liver; Female; Food; Food habits; Gender; Health aspects; Healthy eating index; Hepatic steatosis index; High density lipoprotein; Humans; Insulin resistance; Iran; Lipoproteins; Liver - metabolism; Liver - pathology; Liver diseases; Male; Marital status; Metabolic disorders; Metabolic syndrome; Middle Aged; Non-alcoholic Fatty Liver Disease - blood; Nonalcoholic fatty liver disease; Nutrition; Obesity; Physiology, Pathological; Prevention; Regression analysis; Requirements; Risk factors; Sex differences; Steatosis; Triglycerides; Ultrasonic imaging; Variables; Womens health; Iran; United States > US; Healthy eating index; Nonalcoholic fatty liver disease; Hepatic steatosis index
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-024-03222-x

Obesity, cardiovascular diseases, and metabolic disorders are common problems among participants with non-alcoholic fatty liver disease (NAFLD). However, the association between these problems and the healthy eating index-2015 (HEI-2015) remains unknown. Although the HEI-2015 originated from American dietary guidelines, its comprehensive evaluation of diet quality provides valuable insights for various populations, including Iranians. Therefore, the objective of this study was to investigate the association between anthropometric, hepatic, and cardio-metabolic indices with HEI-2015 scores in participants with NAFLD.
We conducted a cross-sectional analysis of data from the Hoveyzeh Cohort Study, which included adults aged 35 to 70 years between 2016 and 2018. A total of 664 participant with NAFLD (452 females and 212 males) were included in the analysis. The HEI-2015 was assessed using the Food Frequency Questionnaire (FFQ). Various indices, including the body shape index (ABSI), atherogenic index of plasma (AIP), visceral adiposity index (VAI), lipid accumulation product (LAP), cardiometabolic index (CMI), lipoprotein combine index (LCI), AST/ALT ratio, ALD/NAFLD index, and hepatic steatosis index (HSI), were calculated.
No significant differences were observed in anthropometric, cardio-metabolic, and hepatic indices across the quartiles of HEI-2015. However, among participants with NAFLD, men had significantly higher AIP and LCI levels, while women had significantly higher BMI, ABSI, VAI, LAP, and CMI levels. Additionally, women with NAFLD exhibited higher AST/ALT and HSI levels but lower ALD/NAFLD levels compared to men with NAFLD. Linear regression analysis among men with NAFLD revealed a significant negative correlation between HEI-2015 score and HSI in both the unadjusted model (β=-0.131, SE = 0.058, p = 0.024) and the adjusted model for energy intake (β=-0.129, SE = 0.058, p = 0.028).
The present study demonstrated a correlation between lower HEI-2015 scores and an increased risk of steatosis in men with NAFLD. Moreover, our findings highlighted gender-related differences in NAFLD and cardio-metabolic disorders.