Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation

• Published in: International journal of cardiology Vol. 87; no. 2; pp. 259 - 267
• Main Authors: Bae, Jang-Ho, Schwemmer, Michael, Lee, In-Kyu, Lee, Hee-Ja, Park, Ki-Rack, Kim, Ki-Young, Bassenge, Eberhard
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-02-2003; Elsevier Science
• Subjects: Adult; Analysis of Variance; Antioxidants; Antioxidants - administration & dosage; Biological and medical sciences; Blood Flow Velocity; Brachial Artery - physiology; Cardiovascular system; Cohort Studies; Cross-Over Studies; Dietary Fats - administration & dosage; Endothelial dysfunction; Endothelium, Vascular - physiology; Hemodynamics - physiology; Humans; Hypertriglyceridemia; Hypertriglyceridemia - diagnosis; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Lipid oxidation; Lipid Peroxidation - physiology; Male; Malondialdehyde - blood; Medical sciences; Postprandial Period; Probability; Reference Values; Vitamin E - administration & dosage; Antioxidants; Endothelial dysfunction; Hypertriglyceridemia; Lipid oxidation; Lipids; Hyperlipoproteinemia; E-Vitamins; Enzymopathy; Oxidation; Dyslipemia; Mechanism of action; Vascular wall; Human; Regional blood flow; Postprandial; Brachial artery; Metabolic diseases; Antioxidant; Endothelium; Chemotherapy; Treatment; Diet; Fat; Hemodynamics; Comparative study
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/S0167-5273(02)00347-9

Background: To analyze the effects of postprandial hypertriglyceridemia with or without antioxidant supplementation—on endothelial function as related to lipid oxidation in healthy young subjects.
Methods and results: Ten healthy male subjects (mean age: 26 years) were examined three times in fasting state (10 hours) following a high-fat meal, a low-fat meal, or a high-fat meal with additional antioxidant vitamin E (800 IU), respectively. Serum triglycerides significantly increased 2 and 4 hours after eating the high-fat meal with or without additional vitamin E. Endothelium-dependent, flow-mediated brachial artery vasodilations (FMD; percentage change in diameter) changed from 13.3±1.1% to 6.6±1.1% (
p<0.05), 7.1±0.6% (
p<0.05), or 13.2±0.8% at 2, 4, or 6 hours after eating a high-fat meal. However, there were no changes of FMD observed following either a low-fat meal or a high-fat meal with additional vitamin E. The flow-dependent vasodilation inversely correlated to postprandial hypertriglyceridemia (
r=−0.54,
p<0.05). Serum malondialdehydes (MDA; lipid oxidation products) did not significantly change following ingestion of any of the 3 types of meal.
Conclusions: This study suggests that postprandial hypertriglyceridemia-induced endothelial dysfunction is not associated with lipid oxidation and that the protective effects of vitamin E on endothelial function may be due to some alternative, as of yet unknown, mechanism.