Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells

• Published in: Immunology Letters Vol. 68; no. 1; pp. 3 - 15
• Main Authors: Gergely, János, Pecht, Israel, Sármay, Gabriella
• Format: Book Review Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 03-05-1999
• Subjects: Animals; Humans; Immune competent cells; ITAM; ITIM; Lymphocyte Activation; Lymphocytes - immunology; Lymphocytes - metabolism; Mast Cells - immunology; Mast Cells - metabolism; Receptors, Immunologic - physiology; Tyrosine - physiology; ITAM; ITIM; Immune competent cells
• ISSN: 0165-2478; 1879-0542
• DOI: 10.1016/S0165-2478(99)00024-3

ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition.