Effect of depletion of glutathione by buthionine sulfoximine on lipid peroxidation in rats acutely treated with ethanol

1. The effect of depletion of glutathione (GSH) by DL-buthionine-S,R-sulfoximine (BSO) on lipid peroxidation in rats acutely treated with ethanol was investigated. 2. BSO pretreatment has not been found to potentiate an increase in liver, brain and erythrocyte lipid peroxide levels.

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Bibliographic Details
Published in:	International journal of biochemistry Vol. 25; no. 12; p. 1765
Main Authors:	Koçak-Toker, N, Mutlu-Türkoğlu, U, Alptekin, N, Uysal, M
Format:	Journal Article
Language:	English
Published:	England 01-12-1993
Subjects:	Animals Brain - drug effects Brain - metabolism Buthionine Sulfoximine Erythrocytes - drug effects Erythrocytes - metabolism Ethanol - pharmacology Glutathione - deficiency Lipid Peroxidation - physiology Liver - drug effects Liver - metabolism Methionine Sulfoximine - analogs & derivatives Methionine Sulfoximine - metabolism Rats Rats, Sprague-Dawley Time Factors
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Summary:	1. The effect of depletion of glutathione (GSH) by DL-buthionine-S,R-sulfoximine (BSO) on lipid peroxidation in rats acutely treated with ethanol was investigated. 2. BSO pretreatment has not been found to potentiate an increase in liver, brain and erythrocyte lipid peroxide levels.
ISSN:	0020-711X
DOI:	10.1016/0020-711X(88)90305-9